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Full-Text Articles in Cell Biology

Effect Of Α-Synuclein Overexpression On Presynaptic Terminals Of C. Elegans, Christian Silvestri Nov 2014

Effect Of Α-Synuclein Overexpression On Presynaptic Terminals Of C. Elegans, Christian Silvestri

Senior Theses

Parkinson's disease is a non-treatable neurological disorder that can lead to an inability to control one’s own muscles, causing rigidness and lack of movement. α-Synuclein is a protein that has been found in aggregate forms in PD patients and seems to bind to synaptic vesicle membranes and aid in vesicle transporting. This research focuses on the effect that over-expressed forms of α-synuclein have on presynaptic terminals of C. elegans. To examine this relationship we constructed transgenic animals expressing α-synuclein throughout the nervous system of wild type C. elegans. The α-synuclein strain had disruption of the puncta along the ...


Photobiostimulation In C. Elegans As A Model For Low Level Light Therapy, Michael J. Spoto, Daryl D. Hurd Apr 2014

Photobiostimulation In C. Elegans As A Model For Low Level Light Therapy, Michael J. Spoto, Daryl D. Hurd

Science Scholars

Low-Level Laser Therapy (LLLT) is a developing therapeutic technique that has been gaining recognition in the scientific community in recent years. Previous experiments performed in LLLT research projects have been primarily mammalian and cell culture based. These experiments have produced results showing accelerated tissue repair. In this experiment, we introduce a new model, Caenorhabitidis elegans, a free-living soil nematode, to be used in LLLT research by testing the effects of exposure of the organism to various wavelengths and intensities of light commonly used in LLLT. C. elegans was shown to respond to photobiostimulation when exposed to specific wavelengths of Infrared ...


Candida Albicans Als5p Amyloid In Host-Microbe Interactions: A Ceanorhabditis Elegans Study, Michael Bois Feb 2014

Candida Albicans Als5p Amyloid In Host-Microbe Interactions: A Ceanorhabditis Elegans Study, Michael Bois

All Dissertations, Theses, and Capstone Projects

Candida albicans, a dimorphic fungus and an opportunistic pathogen, possesses a myriad of adherence factors including members of the agglutinin-like sequence (Als) family of mannoproteins. The adhesin Als5p mediates adhesion to many substrates, and is upregulated during commensal interactions, but is downregulated during active C. albicans infections[1]. An amyloid forming core sequence at residues 325-331 has been shown to be important for Als5p function, because a single amino acid substitution at position 326 (V326N) greatly reduces Als5p-mediated adherence[2]. We evaluated the role of Als5p in host-microbe interactions, using Caenorhabditis elegans as a host model and feeding them Saccharomyces ...