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Full-Text Articles in Cell Biology

Dicer Cooperates With P53 To Suppress Dna Damage And Skin Carcinogenesis In Mice, Stephen Lyle, Kathleen Hoover, Cansu Colpan, Zhiqing Zhu, Zdenka Matijasevic, Stephen N. Jones Jun 2014

Dicer Cooperates With P53 To Suppress Dna Damage And Skin Carcinogenesis In Mice, Stephen Lyle, Kathleen Hoover, Cansu Colpan, Zhiqing Zhu, Zdenka Matijasevic, Stephen N. Jones

University of Massachusetts Medical School Faculty Publications

Dicer is required for the maturation of microRNA, and loss of Dicer and miRNA processing has been found to alter numerous biological events during embryogenesis, including the development of mammalian skin and hair. We have previously examined the role of miRNA biogenesis in mouse embryonic fibroblasts and found that deletion of Dicer induces cell senescence regulated, in part, by the p53 tumor suppressor. Although Dicer and miRNA molecules are thought to have either oncogenic or tumor suppressing roles in various types of cancer, a role for Dicer and miRNAs in skin carcinogenesis has not been established. Here we show that ...


Genetic Models Of Apoptosis-Induced Proliferation Decipher Activation Of Jnk And Identify A Requirement Of Egfr Signaling For Tissue Regenerative Responses In Drosophila, Yun Fan, Shiuan Wang, Jacob Hernandez, Vildan Betul Yenigun, Gillian Hertlein, Caitlin E. Fogarty, Jillian L. Lindblad, Andreas Bergmann Jan 2014

Genetic Models Of Apoptosis-Induced Proliferation Decipher Activation Of Jnk And Identify A Requirement Of Egfr Signaling For Tissue Regenerative Responses In Drosophila, Yun Fan, Shiuan Wang, Jacob Hernandez, Vildan Betul Yenigun, Gillian Hertlein, Caitlin E. Fogarty, Jillian L. Lindblad, Andreas Bergmann

University of Massachusetts Medical School Faculty Publications

Recent work in several model organisms has revealed that apoptotic cells are able to stimulate neighboring surviving cells to undergo additional proliferation, a phenomenon termed apoptosis-induced proliferation. This process depends critically on apoptotic caspases such as Dronc, the Caspase-9 ortholog in Drosophila, and may have important implications for tumorigenesis. While it is known that Dronc can induce the activity of Jun N-terminal kinase (JNK) for apoptosis-induced proliferation, the mechanistic details of this activation are largely unknown. It is also controversial if JNK activity occurs in dying or in surviving cells. Signaling molecules of the Wnt and BMP families have been ...


A Conserved Flagella-Associated Protein In Chlamydomonas, Fap234, Is Essential For Axonemal Localization Of Tubulin Polyglutamylase Ttll9, Tomohiro Kubo, Haru-Aki Yanagisawa, Zhongmei Liu, Rie Shibuya, Masafumi Hirono, Ritsu Kamiya Jan 2014

A Conserved Flagella-Associated Protein In Chlamydomonas, Fap234, Is Essential For Axonemal Localization Of Tubulin Polyglutamylase Ttll9, Tomohiro Kubo, Haru-Aki Yanagisawa, Zhongmei Liu, Rie Shibuya, Masafumi Hirono, Ritsu Kamiya

University of Massachusetts Medical School Faculty Publications

Tubulin undergoes various posttranslational modifications, including polyglutamylation, which is catalyzed by enzymes belonging to the tubulin tyrosine ligase-like protein (TTLL) family. A previously isolated Chlamydomonas reinhardtii mutant, tpg1, carries a mutation in a gene encoding a homologue of mammalian TTLL9 and displays lowered motility because of decreased polyglutamylation of axonemal tubulin. Here we identify a novel tpg1-like mutant, tpg2, which carries a mutation in the gene encoding FAP234, a flagella-associated protein of unknown function. Immunoprecipitation and sucrose density gradient centrifugation experiments show that FAP234 and TTLL9 form a complex. The mutant tpg1 retains FAP234 in the cell body and flagellar ...