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Full-Text Articles in Cell Biology

Evolutionary Conservation Of A Modified Spermatogenesis Program In Rhabditis Nematodes With Skewed Sex Ratios, Ethan S. Winter May 2014

Evolutionary Conservation Of A Modified Spermatogenesis Program In Rhabditis Nematodes With Skewed Sex Ratios, Ethan S. Winter

Undergraduate Honors Theses

The cellular divisions in Rhabditis sp. SB347 male spermatogenesis have been modified to re-purpose an asymmetric division. This results in the dramatically skewed sex ratios observed in the progeny of males of this species. Here we confirm this asymmetry in the division of tubulin and major sperm protein (MSP). MSP, a necessary sperm component, is segregated exclusively into spermatids bearing the X chromosome while tubulin is segregated into the nullo-X sperm. Timing of the partitioning events reveals that MSP migration is not directly dependent on tubulin spindle asymmetry. Additionally, the endoplasmic reticulum is also segregated asymmetrically to the nullo-X spermatid ...


Modeling Drosophila Stem Cell Development Through Ex Vivo Live-Cell Imaging Studies, Mohima Sanyal Apr 2014

Modeling Drosophila Stem Cell Development Through Ex Vivo Live-Cell Imaging Studies, Mohima Sanyal

Undergraduate Honors Theses

Stem cell specification, maintenance, and differentiation are imperative to proper organogenesis and tissue maintenance. Understanding the mechanisms and steps of these developmental processes is invaluable to advancing tissue grafting, cancer treatment, and other organ therapies. The Drosophila melanogaster testis is one of the best-characterized systems for studying these processes. Currently, studies in the Drosophila testis have thoroughly characterized when stem cells develop and what the resulting adult testis morphology will be. A major question that remains to be answered is how stem cells develop – what controls what cells become functional stem cells and how stem cell fates are dictated. To ...


Primary Cilia Act As Gravity Transducers In Bone Cells, Mustafa Aydogan Jan 2014

Primary Cilia Act As Gravity Transducers In Bone Cells, Mustafa Aydogan

Undergraduate Honors Theses

Environmental mechanical signals play important roles in the cell fate determination of metazoans, including bone tissues, which utilize mechanical stress to balance the amount of bone formation versus bone resorption. In this case, the force due to gravity is essentially a constant mechanical signal on Earth and has been a key factor in the evolution of skeletal systems in vertebrates. Accordingly, changes in this force, such as is experienced under hyperor microgravity conditions, leads to various cellular responses including altered proliferation, migration, and differentiation. Although the modes of response in vertebrate cells to changes in gravitational acceleration have been widely ...