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Full-Text Articles in Cell Biology

Examining Post-Transcriptional Regulation Of Skeletal Muscle Satellite Cell Homeostasis, Activation And Fate Determination, Crystal Dawn Pulliam Jan 2014

Examining Post-Transcriptional Regulation Of Skeletal Muscle Satellite Cell Homeostasis, Activation And Fate Determination, Crystal Dawn Pulliam

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Skeletal muscle is essential for respiration, mobility, reproduction and metabolism. Deficits in muscle function due to disease, injury or age reduce both quality of life and lifespan. Muscles are long-lived tissues that require maintenance to retain functional integrity throughout the life of an organism. Satellite cells are the adult stem cells responsible for muscle repair and maintenance. Upon myotrauma, satellite cells re-enter the cell cycle, proliferate, and terminally differentiate to repair the muscle. In uninjured tissue, satellite cells are quiescent and infrequently proceed through myogenesis for muscle maintenance. The molecular mechanisms that regulate satellite cell quiescence and activation are poorly ...


Characterization Of Microrna Function During Skeletal Myogenesis, Martin G. Guess Jan 2014

Characterization Of Microrna Function During Skeletal Myogenesis, Martin G. Guess

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Skeletal muscle is a remarkable organ system that is required for almost all animal life. In vertebrates, skeletal muscle can alter its functional and molecular characteristics in response to pathologic and physiologic stimuli. Additionally, adult muscle retains the ability to regenerate following injury, activating progenitor cells much like the process of muscle formation during embryonic development. Much work has been done to characterize the changes in gene expression that occur during regeneration, and this knowledge has been invaluable in treatment of muscle wasting diseases, such as Duchenne Muscular Dystrophy. Further expanding the complexity of gene expression changes is the discovery ...


Phosphoregulation Of Sfi1 Is Required For Yeast Centrosome Duplication And Separation, Jennifer Susan Avena Jan 2014

Phosphoregulation Of Sfi1 Is Required For Yeast Centrosome Duplication And Separation, Jennifer Susan Avena

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Centrosomes serve as the main microtubule–organizing centers in many eukaryotic cells. Duplication of centrosomes once per cell cycle is essential for bipolar spindle formation and genome maintenance and requires control by protein kinases, including cyclin–dependent kinases (Cdks). However, an understanding of the mechanisms by which centrosome duplication is regulated and, in particular, restricted to once per cell cycle is still lacking. Sfi1, a conserved component of centrosomes, is a phospho–protein that is a key candidate for establishing the site of new centrosome assembly in the budding yeast Saccharomyces cerevisiae, likely via domain–specific functions. I have examined ...