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2014

Genetics, Development and Cell Biology Publications

Articles 1 - 3 of 3

Full-Text Articles in Cell Biology

Autophagy In Plants And Algae, Diane C. Bassham, Jose L. Crespo Dec 2014

Autophagy In Plants And Algae, Diane C. Bassham, Jose L. Crespo

Genetics, Development and Cell Biology Publications

Autophagy is a major cellular degradation pathway in which materials are delivered to the vacuole in double-membrane vesicles known as autophagosomes, broken down, and recycled (Li and Vierstra, 2012; Liu and Bassham, 2012). In photosynthetic organisms, the pathway is strongly activated by biotic and abiotic stresses, including nutrient limitation, oxidative, salt and drought stress and pathogen infection, and during senescence (Perez-Perez et al., 2012; Lv et al., 2014). Mutation of genes required for autophagy causes hypersensitivity to stress, indicating that autophagy is important for tolerance of multiple stresses. While autophagy is often non-selective, a growing number of examples of selectivity ...


Loss Of Gq/11 Genes Does Not Abolish Melanopsin Phototransduction, Kylie S. Chew, Tiffany M. Schmidt, Alan C. Rupp, Paulo Kofuji, Jeffrey M. Trimarchi Jan 2014

Loss Of Gq/11 Genes Does Not Abolish Melanopsin Phototransduction, Kylie S. Chew, Tiffany M. Schmidt, Alan C. Rupp, Paulo Kofuji, Jeffrey M. Trimarchi

Genetics, Development and Cell Biology Publications

In mammals, a subset of retinal ganglion cells (RGCs) expresses the photopigment melanopsin, which renders them intrinsically photosensitive (ipRGCs). These ipRGCs mediate various non-image-forming visual functions such as circadian photoentrainment and the pupillary light reflex (PLR). Melanopsin phototransduction begins with activation of a heterotrimeric G protein of unknown identity. Several studies of melanopsin phototransduction have implicated a G-protein of the Gq/11 family, which consists of Gna11, Gna14, Gnaq and Gna15, in melanopsin-evoked depolarization. However, the exact identity of the Gq/11 gene involved in this process has remained elusive. Additionally, whether Gq/11 G-proteins are necessary for melanopsin phototransduction ...


Onecut1 And Onecut2 Play Critical Roles In The Development Of The Mouse Retina, Jillian J. Goetz, Gregory M. Martin, Rebecca Chowdhury, Jeffrey M. Trimarchi Jan 2014

Onecut1 And Onecut2 Play Critical Roles In The Development Of The Mouse Retina, Jillian J. Goetz, Gregory M. Martin, Rebecca Chowdhury, Jeffrey M. Trimarchi

Genetics, Development and Cell Biology Publications

The entire repertoire of intrinsic factors that control the cell fate determination process of specific retinal neurons has yet to be fully identified. Single cell transcriptome profiling experiments of retinal progenitor cells revealed considerable gene expression heterogeneity between individual cells, especially among different classes of transcription factors. In this study, we show that two of those factors, Onecut1 and Onecut2, are expressed during mouse retinal development. Using mice that are deficient for each of these transcription factors, we further demonstrate a significant loss (∼70–80%) of horizontal cells in the absence of either of these proteins, while the other retinal ...