Open Access. Powered by Scholars. Published by Universities.®

Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 3 of 3

Full-Text Articles in Cell Biology

The Role Of Stem Cells In Adipose Tissue Remodeling., Candice Reshay Holden 1988- Dec 2014

The Role Of Stem Cells In Adipose Tissue Remodeling., Candice Reshay Holden 1988-

Electronic Theses and Dissertations

The work presented in this dissertation outlines the role of stem cells in the remodeling of adipose tissue under conditions of nutrient excess. Obesity-induced variations in adipose tissue stem cell distribution were uncovered by analysis of the stromal vascular fraction isolated from mice fed a high fat diet for several weeks. Bone marrow cell transplantation was used to determine the derivation of progenitor cells found in adipose tissue; and supplementation of depleted progenitor cell populations achieved via direct cell transplantation, helped to determine the contribution of these progenitor cells to the remodeling process. The dissertation is presented in five chapters ...


Regulation Of Chromosome Segregation In Drosophila Meiosis, Zhi Hao Guo Jan 2014

Regulation Of Chromosome Segregation In Drosophila Meiosis, Zhi Hao Guo

Electronic Theses and Dissertations

Sister-chromatid cohesion is maintained by Cohesin complex. Separase releases the cohesion through the cleavage of the kleisin subunit of Cohesin complex. Separase is regulated by its inhibitor, Securin/Pim. These processes are well studied in mitosis but little is known for meiosis. I found that Separase is required for the proper separation of homologous chromosomes and sister chromatids in Drosophila meiosis. Its function is inhibited by Securin/Pim during the process. I showed that the common kleisin subunit, Rad21, is not likely to be the meiotic target of Separase and that Rad21 and another common Cohesin component, SMC3/CAP, does ...


Cellular Coping Mechanisms To Hypoxia In The Longhorn Sculpin (Myoxocephalus Octodecemspinosus) Brain, Kelly Heino Jan 2014

Cellular Coping Mechanisms To Hypoxia In The Longhorn Sculpin (Myoxocephalus Octodecemspinosus) Brain, Kelly Heino

Electronic Theses and Dissertations

The loss of neurological function due to hypoxia remains to be a challenge in many species due to the lack of knowledge and understanding of cellular responses. To investigate cellular responses and survival strategies of the brain during hypoxia and post-hypoxia recovery in a moderate hypoxia-tolerant species, with the hopes of identifying possible therapeutic remedies, thirty Longhorn sculpin, Myoxocephalus octodecimspinosus, were challenged with acute hypoxia (40% O2 saturation for 1 h) and twelve additional sculpin were used as controls (~90% O2 saturation). Fish were sampled at each of the following time points: control/normoxic conditions (T=0 h); hypoxic ...