Open Access. Powered by Scholars. Published by Universities.®

Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

PDF

2014

Selected Works

Physiology

Testosterone

Articles 1 - 1 of 1

Full-Text Articles in Cell Biology

Measurements Of Serum Mullerian Inhibiting Substance In The Evaluation Of Children With Nonpalpable Gonads, Mary M. Lee, Patricia K. Donahoe, B. L. Silverman, T. Hasegawa, Yasuhiro Hasegawa, M. L. Gustafson, Y. C. Chang, David T. Maclaughlin Sep 2014

Measurements Of Serum Mullerian Inhibiting Substance In The Evaluation Of Children With Nonpalpable Gonads, Mary M. Lee, Patricia K. Donahoe, B. L. Silverman, T. Hasegawa, Yasuhiro Hasegawa, M. L. Gustafson, Y. C. Chang, David T. Maclaughlin

Mary M. Lee

BACKGROUND: Mullerian inhibiting substance, produced constitutively by the prepubertal testes, promotes involution of the mullerian ducts during normal male sexual differentiation. In children with virilization and nonpalpable gonads, only those with testicular tissue should have detectable serum concentrations of mullerian inhibiting substance. METHODS: We measured serum mullerian inhibiting substance in 65 children with virilization at birth and nonpalpable gonads (age at diagnosis, 2 days to 11 years) and serum testosterone in 54 of them either after the administration of human chorionic gonadotropin or during the physiologic rise in testosterone that occurs in normal infants. RESULTS: The mean (+/-SD) serum mullerian ...