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2012

Aging; Reactive Oxygen Species; DNA, Mitochondrial

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Full-Text Articles in Cell Biology

Oxidative Stress, Mitochondrial Dysfunction, And Aging, Hang Cui, Yahui Kong, Hong Zhang Oct 2012

Oxidative Stress, Mitochondrial Dysfunction, And Aging, Hang Cui, Yahui Kong, Hong Zhang

Open Access Articles

Aging is an intricate phenomenon characterized by progressive decline in physiological functions and increase in mortality that is often accompanied by many pathological diseases. Although aging is almost universally conserved among all organisms, the underlying molecular mechanisms of aging remain largely elusive. Many theories of aging have been proposed, including the free-radical and mitochondrial theories of aging. Both theories speculate that cumulative damage to mitochondria and mitochondrial DNA (mtDNA) caused by reactive oxygen species (ROS) is one of the causes of aging. Oxidative damage affects replication and transcription of mtDNA and results in a decline in mitochondrial function which in ...