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2002

Animals; Bone Resorption; Carrier Proteins; Chromosome Mapping; Chromosomes; Flow Cytometry; Humans; Lymph Nodes; Membrane Glycoproteins; Mice; Mice, Knockout; Osteoclasts; Osteopetrosis; Phenotype; RANK Ligand; Rats; Receptor Activator of Nuclear Factor-kappa B; Tumor Necrosis Factor-alpha

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Full-Text Articles in Cell Biology

Evidence That The Rat Osteopetrotic Mutation Toothless (Tl) Is Not In The Tnfsf11 (Trance, Rankl, Odf, Opgl) Gene, Paul R. Odgren, Nacksung Kim, Liesbeth Van Wesenbeeck, Carole A. Mackay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim Van-Hul, Yongwon Choi, Sandy C. Marks Jr. Jan 2002

Evidence That The Rat Osteopetrotic Mutation Toothless (Tl) Is Not In The Tnfsf11 (Trance, Rankl, Odf, Opgl) Gene, Paul R. Odgren, Nacksung Kim, Liesbeth Van Wesenbeeck, Carole A. Mackay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim Van-Hul, Yongwon Choi, Sandy C. Marks Jr.

Open Access Articles

The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required for normal osteoclast differentiation. Although the genetic locus remains unknown, the phenotypic impact of the tl mutation on multiple systems has been well characterized. Some of its actions are similar to tumornecrosis factor superfamily member 11(TNFSF11; also called TRANCE, RANKL, ODF and OPGL) null mice. TNFSF11 is a recently described member of the tumor necrosis factor superfamily which, when expressed by activated T cells, enhances the survival of antigen-presenting dendritic cells, and when expressed by osteoblasts, promotes the differentiation and activation of osteoclasts. The ...