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Cell Biology Commons

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2002

Animals; Blindness; Cattle; Chlamydomonas; Cilia; Flagella; Male; Mice; Mice, Mutant Strains; Molecular Sequence Data; Mutagenesis, Insertional; Opsin; Proteins; Protozoan Proteins; Rabbits; Rods (Retina); Testis; Transport Vesicles; *Tumor Suppressor Proteins

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Full-Text Articles in Cell Biology

The Intraflagellar Transport Protein, Ift88, Is Essential For Vertebrate Photoreceptor Assembly And Maintenance, Gregory J. Pazour, Sheila A. Baker, James A. Deane, Douglas G. Cole, Bethany L. Dickert, Joel L. Rosenbaum, George B. Witman, Joseph C. Besharse Mar 2002

The Intraflagellar Transport Protein, Ift88, Is Essential For Vertebrate Photoreceptor Assembly And Maintenance, Gregory J. Pazour, Sheila A. Baker, James A. Deane, Douglas G. Cole, Bethany L. Dickert, Joel L. Rosenbaum, George B. Witman, Joseph C. Besharse

Open Access Articles

Approximately 10% of the photoreceptor outer segment (OS) is turned over each day, requiring large amounts of lipid and protein to be moved from the inner segment to the OS. Defects in intraphotoreceptor transport can lead to retinal degeneration and blindness. The transport mechanisms are unknown, but because the OS is a modified cilium, intraflagellar transport (IFT) is a candidate mechanism. IFT involves movement of large protein complexes along ciliary microtubules and is required for assembly and maintenance of cilia. We show that IFT particle proteins are localized to photoreceptor connecting cilia. We further find that mice with a mutation ...