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2002

Actinin; Animals; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Excitatory Amino Acid Agonists; Glutathione Transferase; Macromolecular Substances; Mice; Nerve Tissue Proteins; Neurons; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Signal Transduction; Two-Hybrid System Techniques

Articles 1 - 1 of 1

Full-Text Articles in Cell Biology

The Cyclin-Dependent Kinase 5 Activators P35 And P39 Interact With The Alpha-Subunit Of Ca2+/Calmodulin-Dependent Protein Kinase Ii And Alpha-Actinin-1 In A Calcium-Dependent Manner, Rani Dhavan, Paul L. Greer, Maria A. Morabito, Lianna R. Orlando, Li-Huei Tsai Sep 2002

The Cyclin-Dependent Kinase 5 Activators P35 And P39 Interact With The Alpha-Subunit Of Ca2+/Calmodulin-Dependent Protein Kinase Ii And Alpha-Actinin-1 In A Calcium-Dependent Manner, Rani Dhavan, Paul L. Greer, Maria A. Morabito, Lianna R. Orlando, Li-Huei Tsai

Morabito Lab Publications

Cyclin-dependent kinase 5 (Cdk5) is a critical regulator of neuronal migration in the developing CNS, and recent studies have revealed a role for Cdk5 in synaptogenesis and regulation of synaptic transmission. Deregulation of Cdk5 has been linked to the pathology of neurodegenerative diseases such as Alzheimer's disease. Activation of Cdk5 requires its association with a regulatory subunit, and two Cdk5 activators, p35 and p39, have been identified. To gain further insight into the functions of Cdk5, we identified proteins that interact with p39 in a yeast two-hybrid screen. In this study we report that alpha-actinin-1 and the alpha-subunit of ...