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2002

Acrylic Resins; Animals; Cells, Cultured; Lysophospholipids; Macrophages; Mice; Mice, Inbred C3H; Microfilaments; Opsonin Proteins; Particle Size; *Phagocytosis; Receptors, Fc; Stress, Mechanical; rac1 GTP-Binding Protein

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Full-Text Articles in Cell Biology

Fc-Receptor-Mediated Phagocytosis Is Regulated By Mechanical Properties Of The Target, Karen A. Beningo, Yu-Li Wang Feb 2002

Fc-Receptor-Mediated Phagocytosis Is Regulated By Mechanical Properties Of The Target, Karen A. Beningo, Yu-Li Wang

Open Access Articles

Phagocytosis is an actin-based process used by macrophages to clear particles greater than 0.5 microm in diameter. In addition to its role in immunological responses, phagocytosis is also necessary for tissue remodeling and repair. To prevent catastrophic autoimmune reactions, phagocytosis must be tightly regulated. It is commonly assumed that the recognition/selection of phagocytic targets is based solely upon receptor-ligand binding. Here we report an important new criterion, that mechanical parameters of the target can dramatically affect the efficiency of phagocytosis. When presented with particles of identical chemical properties but different rigidity, macrophages showed a strong preference to engulf ...