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Full-Text Articles in Cell Biology

The D0 Domain Of Kir3d Acts As A Major Histocompatibility Complex Class I Binding Enhancer, Salim I. Khakoo, Ron Geller, Sunny Shin, Jomaquai A. Jenkins, Peter Parham Oct 2002

The D0 Domain Of Kir3d Acts As A Major Histocompatibility Complex Class I Binding Enhancer, Salim I. Khakoo, Ron Geller, Sunny Shin, Jomaquai A. Jenkins, Peter Parham

Department of Microbiology Papers

In contrast to the KIR2D:HLA-C interaction, little is known of KIR3DL1's interaction with HLA-B or the role of D0, the domain not present in KIR2D. Differences in the strength and specificity for major histocompatibility complex class I of KIR3DL1 and its common chimpanzee homologue Pt-KIR3DL1/2 were exploited to address these questions. Domain-swap, deletion, and site-directed mutants of KIR3DL1 were analyzed for HLA-B binding using a novel, positively signaling cell–cell binding assay. Natural ‘deletion’ of residues 50 and 51 from its D0 domain causes Pt-KIR3DL1/2 to bind Bw4+ HLA-B allotypes more avidly than does KIR3DL1. Deletion ...


Evidence That The Rat Osteopetrotic Mutation Toothless (Tl) Is Not In The Tnfsf11 (Trance, Rankl, Odf, Opgl) Gene, Paul R. Odgren, Nacksung Kim, Liesbeth Van Wesenbeeck, Carole A. Mackay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim Van-Hul, Yongwon Choi, Sandy C. Marks Jr. Jan 2002

Evidence That The Rat Osteopetrotic Mutation Toothless (Tl) Is Not In The Tnfsf11 (Trance, Rankl, Odf, Opgl) Gene, Paul R. Odgren, Nacksung Kim, Liesbeth Van Wesenbeeck, Carole A. Mackay, April Mason-Savas, Fayez F. Safadi, Steven N. Popoff, Christopher J. Lengner, Wim Van-Hul, Yongwon Choi, Sandy C. Marks Jr.

Open Access Articles

The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required for normal osteoclast differentiation. Although the genetic locus remains unknown, the phenotypic impact of the tl mutation on multiple systems has been well characterized. Some of its actions are similar to tumornecrosis factor superfamily member 11(TNFSF11; also called TRANCE, RANKL, ODF and OPGL) null mice. TNFSF11 is a recently described member of the tumor necrosis factor superfamily which, when expressed by activated T cells, enhances the survival of antigen-presenting dendritic cells, and when expressed by osteoblasts, promotes the differentiation and activation of osteoclasts. The ...


Variability Of Placental Expression Of Cyclin E Low Molecular Weight Variants, A Bukovsky, Maria Cekanova Ms, Rndr, Phd, Mr Caudle, J Wimalasena, Js Foster, Ja Keenan, Rf Elder Jan 2002

Variability Of Placental Expression Of Cyclin E Low Molecular Weight Variants, A Bukovsky, Maria Cekanova Ms, Rndr, Phd, Mr Caudle, J Wimalasena, Js Foster, Ja Keenan, Rf Elder

Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology

No abstract provided.


Improved Energy Model For Membrane Electroporation In Biological Cells Subjected To Electrical Pulses, R. P. Joshi, Q. Hu, K. H. Schoenbach, H. P. Hjalmarson Jan 2002

Improved Energy Model For Membrane Electroporation In Biological Cells Subjected To Electrical Pulses, R. P. Joshi, Q. Hu, K. H. Schoenbach, H. P. Hjalmarson

Bioelectrics Publications

A self-consistent model analysis of electroporation in biological cells has been carried out based on an improved energy model. The simple energy model used in the literature is somewhat incorrect and unphysical for a variety of reasons. Our model for the pore formation energy E(r) includes a dependence on pore population and density. It also allows for variable surface tension, incorporates the effects of finite conductivity on the electrostatic correction term, and is dynamic in nature. Self-consistent calculations, based on a coupled scheme involving the Smoluchowski equation and the improved energy model, are presented. It is shown that E ...