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Full-Text Articles in Cell Biology

Netrin-3 Peptide (C-19) Is A Chemorepellent And A Growth Inhibitor In Tetrahymena Thermophila, Jennifer N. Felzien, Brandon R. Kalb, Bethany C. Khol, Katelyn R. Malik, Matthew S. Merical, Lois Parks, David Paulding, Shannon Rappaport, Kenneth W. Ward, Heather G. Kuruvilla Apr 2017

Netrin-3 Peptide (C-19) Is A Chemorepellent And A Growth Inhibitor In Tetrahymena Thermophila, Jennifer N. Felzien, Brandon R. Kalb, Bethany C. Khol, Katelyn R. Malik, Matthew S. Merical, Lois Parks, David Paulding, Shannon Rappaport, Kenneth W. Ward, Heather G. Kuruvilla

The Research and Scholarship Symposium (2013-2019)

The netrins are a family of signaling proteins expressed throughout the animal kingdom. Netrins play important roles in developmental processes such as axonal guidance and angiogenesis. Netrin-1, for example, can act as either a chemoattractant or a chemorepellent for axonal growth cones depending upon the concentration of the protein as well as the cell type. Netrin-1 acts as a growth factor in some mammalian cell types and is also expressed by some tumor cells. Netrin-3 appears to share some signaling apparatus with netrin-1, but is less widely expressed, and its physiological roles are much less understood. Netrin-3 is also used ...


Immunolocalization Of A Netrin-3 Like Peptide In Tetrahymena Thermophila Using Antibodies Against The N- And C-Terminus Of The Protein, Bethany C. Khol, Katelyn R. Malik, Heather G. Kuruvilla Apr 2017

Immunolocalization Of A Netrin-3 Like Peptide In Tetrahymena Thermophila Using Antibodies Against The N- And C-Terminus Of The Protein, Bethany C. Khol, Katelyn R. Malik, Heather G. Kuruvilla

The Research and Scholarship Symposium (2013-2019)

Tetrahymena thermophila are free-living, unicellular, eukaryotic protozoans that live in a variety of aquatic environments. These organisms interact with their environment by responding to chemorepellents and chemoattractants which direct them toward favorable stimuli, such as food, and away from unfavorable stimuli, such as predators. We have previously described two netrin-like proteins, a netrin-1 like protein, and a netrin-3 like protein, which are secreted from Tetrahymena. Both of these proteins act as chemorepellents, and may allow cells to communicate with each other regarding population density, preventing them from outgrowing the available environmental resources. In our current study, we used antibodies against ...