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Full-Text Articles in Cell Biology

Optimizing Microfluidic Design For Cell Separation, Joseph Wakim, Marisel De Jesus Vega, Nese Orbey, Carol Barry May 2017

Optimizing Microfluidic Design For Cell Separation, Joseph Wakim, Marisel De Jesus Vega, Nese Orbey, Carol Barry

UMass Center for Clinical and Translational Science Research Retreat

To evaluate the performance of various designs of crossflow filtration microfluidic devices, blood flow was modeled using computational fluid dynamics software (COMSOL Multiphysics). Velocity profiles were generated and used to analyze four critical design parameters: pillar size, pillar shape, gap size, and wall length. These parameters were optimized to yield greatest flow from an unfiltered main channel into two filtered side channels of the device, thereby maximizing filtration capacity.

Devices containing pillars of 10 µm diameter yielded a significantly greater filtration capacity than devices with pillars of 20 µm diameter. Flow patterns from the main channel to the side channels ...