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Extracellular Atp Effects On Intracellular Actin Fibrils' Location And Characteristics, Dianna Huisman
Research in the Capitol
Epithelial cells lining secretory units and ducts of bovine mammary glands perform an important role in regulating movement of various macromolecules and whole cells during normal lactation and mastitis. During mastitis, host and bacterial produced substances can affect the “barrier” function of epithelial monolayers. One potential component is adenosine triphosphate (ATP). ATP likely interacts with P2X7, a purinergic receptor, in mediating some effects associated with mastitis. Bovine mammary gland epithelial cell line, Mac-T cells, were examined for cytoskeletal changes as result of P2X7 interactions. Actin cytoskeletons were stained with phalloidin and effects were examined by fluorescent microscopy. Observable increase in ...