Open Access. Powered by Scholars. Published by Universities.®

Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 3 of 3

Full-Text Articles in Cell Biology

The Varus Knee Reveals Differential Expression Patterns Of Mirnas In Spared Vs. Non-Spared Compartments, Paul J. Fanning, Brian Ayers, Marie Walcott, Gary S. Stein, David C. Ayers, Jane B. Lian May 2012

The Varus Knee Reveals Differential Expression Patterns Of Mirnas In Spared Vs. Non-Spared Compartments, Paul J. Fanning, Brian Ayers, Marie Walcott, Gary S. Stein, David C. Ayers, Jane B. Lian

UMass Center for Clinical and Translational Science Research Retreat

Introduction MicroRNAs (miRNAs) function by repressing cellular protein levels to provide a sophisticated level of gene regulation that coordinates a broad spectrum of biological processes. MiRNA inhibition of mRNA translation has emerged as an important regulator of chondrogenic and osteogenic development, osteoblast, osteoclast and chondrocyte cell growth and differentiation, and tissue homeostasis in the adult skeleton. MiRNAs control many layers of regulation in adult tissues connected to both normal biological and pathologic cellular activities. The study of miRNAs in skeletal disorders is in its infancy. Osteoarthritis (OA) is a disease that progresses from degeneration of the articular cartilage to remodeling ...


Etiology Of Experimental Osteoarthritis: Early Events And Potential Clinical Implications, Paul J. Fanning, Jason Silva, Julianne Marvin, Kirti Basil, Marie Walcott, David C. Ayers May 2012

Etiology Of Experimental Osteoarthritis: Early Events And Potential Clinical Implications, Paul J. Fanning, Jason Silva, Julianne Marvin, Kirti Basil, Marie Walcott, David C. Ayers

UMass Center for Clinical and Translational Science Research Retreat

Introduction Osteoarthritis (OA) is the most common form of arthritis and accounts for 50% of all chronic conditions in the elderly. One in two adults reported a chronic musculoskeletal condition in 2005, twice the rate of reported chronic heart or respiratory conditions(2). In addition, persons aged 45 to 64 account for an increasingly greater proportion of total musculoskeletal disease treatment costs and lost wages, a trend that will continue for the next several decades(3). Surgical treatment culminating in total joint replacement (TJR) remains the most effective therapy for late stage OA. Current treatment of pre-surgical OA consists of ...


Viral Receptor Trafficking Regulated By Gabarap, Cendy Valle Oseguera, Carolyn C. Tu, Jie Sun, Kathleen Arnolds, Juliet V. Spencer Apr 2012

Viral Receptor Trafficking Regulated By Gabarap, Cendy Valle Oseguera, Carolyn C. Tu, Jie Sun, Kathleen Arnolds, Juliet V. Spencer

Creative Activity and Research Day - CARD

Human cytomegalovirus (HCMV) is a widespread pathogen that can be life-threatening to immune-compromised patients but rarely causes disease in healthy individuals. Previous work using the yeast two-hybrid system found that GABARAP (γ-aminobutyric-acid-receptor-associated-protein) binds to HCMV US27. US27 is similar to human chemokine receptors, but is localized intracellularly instead of on the surface. Here, we examined the US27-GABARAP interaction in human cells and identified a four amino acid motif (WXXL) that mediates GABARAP binding to US27 and its localization to endosomal compartments. Since GABARAP regulates cellular receptor trafficking, these results show that viral US27 is also controlled by a cellular protein.