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Symposium on Undergraduate Research and Creative Expression

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Full-Text Articles in Cell Biology

Exploring Distinct Retinal Ganglion Cell Types At Single Cell Resolution, Terry Lund Apr 2014

Exploring Distinct Retinal Ganglion Cell Types At Single Cell Resolution, Terry Lund

Symposium on Undergraduate Research and Creative Expression

Glaucoma is a degenerative disease of the eye, characterized by the gradual death of the optic nerve and the retinal ganglion cells that comprise it. The literature tells us that these cells do not die uniformly. To understand why this is, it is imperative we have a robust understanding of the retinal ganglion cell; however, characterization has been difficult and no good genetic profile exists for all the various sub-types. Our research examines retinal ganglion cells at single cell resolution on microarrays. Using these data, we are able to visualize candidate genes expressed in retinal ganglion cell sub-types with in ...


The Role Of Maternally Supplied Cell Death Components In Primordial Germ Cell Development Of Drosophila Melanogaster, Danielle Pohl Apr 2014

The Role Of Maternally Supplied Cell Death Components In Primordial Germ Cell Development Of Drosophila Melanogaster, Danielle Pohl

Symposium on Undergraduate Research and Creative Expression

During development, Drosophila melanogaster primordial germ cells migrate from the posterior pole to the somatic gonadal precursor cells, where they form the gonads. During this migratory process, about half of the germ cells die via an unknown mechanism. Maternally supplied gene products play a large role in germ cell development. The mother deposits mRNA into the egg, which is expressed prior to embryonic transcriptional activation. This project investigates the contribution of maternally supplied cell death components on the primordial germ cell development in the embryo. In particular, the apoptotic pathway is under investigation. To generate maternal loss-of-function conditions, germ line ...