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University of North Georgia

Cardiovascular Diseases

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Full-Text Articles in Cell Biology

Development Of Fret Biosensors To Detect Kinase Activity In Living Cells, Jenny Okáľová Nov 2019

Development Of Fret Biosensors To Detect Kinase Activity In Living Cells, Jenny Okáľová

Georgia Undergraduate Research Conference (GURC)

Development of FRET Biosensors to Detect Kinase Activity in Living Cells
Jenny Okáľová, Undergraduate Research Assistant and CURO Honors Scholar
Dr. Neil J. Grimsey, Pharmaceutical and Biomedical Sciences, College of Pharmacy

G-protein-coupled receptors (GPCRs) are a group of over 800 membrane receptors that induce intracellular signaling cascades to interpret an array of external signals. The p38 mitogen-activated protein kinase (MAPK) pathway plays a key role in inflammatory responses found in many diseases. Our group discovered a family of GPCRs that regulate an atypical pathway for p38 activation in vascular cells. This atypical pathway specifically requires transforming growth factor-β (TGFβ) activated ...