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Full-Text Articles in Cell Biology

Pulmonary Surfactant Fortified With Cath-2 As A Novel Therapy For Bacterial Pneumonia, Brandon J. Baer Mar 2017

Pulmonary Surfactant Fortified With Cath-2 As A Novel Therapy For Bacterial Pneumonia, Brandon J. Baer

Western Research Forum

Background: Bacterial pneumonia is a leading cause of death worldwide, with high mortality rates persisting even after antibiotic treatment. Current treatments for pneumonia involve administration of antibiotics, however after the bacteria are killed they release toxic substances that induce inflammation and lung dysfunction. Host defense peptides represent a potential solution to this problem through their ability to down regulate inflammation. However, effective delivery to the lung is difficult because of the complex branching structure of the airways. My study addresses this delivery problem by using exogenous surfactant, a pulmonary delivery vehicle capable of improving spreading of these peptides throughout the ...


High Performance Amphiphilic Polymer/Hydroxyapatite Composite Tissue Scaffolds, Artem B. Kutikov, Jie Song May 2014

High Performance Amphiphilic Polymer/Hydroxyapatite Composite Tissue Scaffolds, Artem B. Kutikov, Jie Song

UMass Center for Clinical and Translational Science Research Retreat

There is a critical clinical need for alternatives to autograft and allograft bone for over 500,000 bone grafting operations performed each year in the United States. Current synthetic bone grafts suffer from poor handling characteristics, brittle mechanical properties, and inconsistent bioactivity. By blending a biodegradable amphiphilic polymer with hydroxyapatite (HA), the main mineral component in bone, we developed an improved synthetic bone graft. The polymer/HA composites were fabricated in both 2-D and 3-D forms by electrospinning and 3-D printing. These materials exhibited unique handling characteristics such as high tensile elasticity (>200% failure strain) and self-stiffening properties upon hydration ...


Molecular Mechanisms Of Fsh Muscular Dystrophy Pathogenesis, Peter L. Jones, Takako I. Jones May 2013

Molecular Mechanisms Of Fsh Muscular Dystrophy Pathogenesis, Peter L. Jones, Takako I. Jones

UMass Center for Clinical and Translational Science Research Retreat

Discussion of a new research initiative at UMass Medical School focused on the pathogenesis of Facioscapulohumeral Muscular Dystrophy (FSHD) and efforts towards diagnostics and therapeutics. This presentation is part of the retreat mini-symposium entitled: Neuromuscular Diseases: Pathogenesis and the Road to Therapeutics.


Estrogen Receptor Beta Selectively Restricts Proliferation And Favors Surveillance In Mammary Epithelial Cells, Karen A. Dunphy, Erick Roman-Perez, Rehaneh Hooshyar, Mary J. Hagen, Amy L. Roberts, Mara Isel Guerrero-Zayas, D. Joseph Jerry May 2013

Estrogen Receptor Beta Selectively Restricts Proliferation And Favors Surveillance In Mammary Epithelial Cells, Karen A. Dunphy, Erick Roman-Perez, Rehaneh Hooshyar, Mary J. Hagen, Amy L. Roberts, Mara Isel Guerrero-Zayas, D. Joseph Jerry

UMass Center for Clinical and Translational Science Research Retreat

Estrogen (17β-estradiol) has paradoxical effects in both promoting and preventing breast cancer as estrogen activates proliferation, but also promotes p53-mediated surveillance pathways. Estrogen mediates its effects in target tissues through the activation of estrogen receptor subtypes: ERα and ERβ. To examine the capability of these receptors in mediating surveillance as opposed to proliferation, selective estrogen receptor agonists were compared with 17β-estradiol for induction of proliferation and radiation induced apoptosis in vivo. Transcriptional regulation of estrogen-responsive genes was also compared in mouse mammary epithelium in vivo and in the human mammary MCF7 cell line transduced with a repressible ERβ. Selective activation ...


The Varus Knee Reveals Differential Expression Patterns Of Mirnas In Spared Vs. Non-Spared Compartments, Paul J. Fanning, Brian Ayers, Marie Walcott, Gary S. Stein, David C. Ayers, Jane B. Lian May 2012

The Varus Knee Reveals Differential Expression Patterns Of Mirnas In Spared Vs. Non-Spared Compartments, Paul J. Fanning, Brian Ayers, Marie Walcott, Gary S. Stein, David C. Ayers, Jane B. Lian

UMass Center for Clinical and Translational Science Research Retreat

Introduction MicroRNAs (miRNAs) function by repressing cellular protein levels to provide a sophisticated level of gene regulation that coordinates a broad spectrum of biological processes. MiRNA inhibition of mRNA translation has emerged as an important regulator of chondrogenic and osteogenic development, osteoblast, osteoclast and chondrocyte cell growth and differentiation, and tissue homeostasis in the adult skeleton. MiRNAs control many layers of regulation in adult tissues connected to both normal biological and pathologic cellular activities. The study of miRNAs in skeletal disorders is in its infancy. Osteoarthritis (OA) is a disease that progresses from degeneration of the articular cartilage to remodeling ...


Etiology Of Experimental Osteoarthritis: Early Events And Potential Clinical Implications, Paul J. Fanning, Jason Silva, Julianne Marvin, Kirti Basil, Marie Walcott, David C. Ayers May 2012

Etiology Of Experimental Osteoarthritis: Early Events And Potential Clinical Implications, Paul J. Fanning, Jason Silva, Julianne Marvin, Kirti Basil, Marie Walcott, David C. Ayers

UMass Center for Clinical and Translational Science Research Retreat

Introduction Osteoarthritis (OA) is the most common form of arthritis and accounts for 50% of all chronic conditions in the elderly. One in two adults reported a chronic musculoskeletal condition in 2005, twice the rate of reported chronic heart or respiratory conditions(2). In addition, persons aged 45 to 64 account for an increasingly greater proportion of total musculoskeletal disease treatment costs and lost wages, a trend that will continue for the next several decades(3). Surgical treatment culminating in total joint replacement (TJR) remains the most effective therapy for late stage OA. Current treatment of pre-surgical OA consists of ...