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Full-Text Articles in Cell Biology

The Effects Of Sugars On Lactobacillus Casei Growth, Alexis Felty, Sidney Gerkin, Taylor Kowalski, Parker Williams Dec 2018

The Effects Of Sugars On Lactobacillus Casei Growth, Alexis Felty, Sidney Gerkin, Taylor Kowalski, Parker Williams

Undergraduate Research Symposium (URS)

The Western culture tends to deem the Eastern culture as obese and unhealthy due to the large amounts of saturated fats and abundance of sugars that it consumes. Some studies argue that Lactobacillus casei can alter health and researchers are attempting to prove that different sugars, natural or artificial, have different effects on the growth of L. casei [1]. L. casei was chosen as the experimental model due to easily replicable growing conditions and the importance of the bacteria in the gut microbiome.

Sugar-bacteria solutions were created and their turbidities were taken to quantify the amount of bacteria growth after ...


Analyzing The Efficacy Of Natural Baby Soaps For The Elimination Of Bacterial Colonization On Bath Toys, Abigail Rost, Jacqueline Benitez, Mira Nicpon, Katelyn Mclaughlin Dec 2018

Analyzing The Efficacy Of Natural Baby Soaps For The Elimination Of Bacterial Colonization On Bath Toys, Abigail Rost, Jacqueline Benitez, Mira Nicpon, Katelyn Mclaughlin

Undergraduate Research Symposium (URS)

Recent studies have discovered that water-retaining bath toys harbor a high amount of potential pathogens due to available nutrients in baby soaps. Unfortunately , these bath toys can be a source for infection or disease for the children playing with them. In order to investigate the efficacy of baby soaps on the elimination of bacteria on bath toys, rubber ducks were coated with E. coli and then were washed with an organic or non-organic baby soap. It was hypothesized that organic soap would be more efficient at eliminating bacteria due to its antibacterial properties. Through this experiment, it was found that ...


Vitamin E: A Possible Preventative Measure For Cte, Dylan Roth, Cameron Dargis Dec 2018

Vitamin E: A Possible Preventative Measure For Cte, Dylan Roth, Cameron Dargis

Undergraduate Research Symposium (URS)

Introduction

This experiment is aimed to aide all future athletes.

•The brain injury known as CTE can only be diagnosed after death and upon autopsy.

•Upon research, what causes this is non-heme Iron deposits in the brain cause radical oxygen species that damage the nerve cells.

•Causes many different mental and physical problems

•Research on Vitamin E showed that it can accept radical oxygen species and increase neurological health.

•We will be testing these affects on yeast samples

Hypothesis

If yeast is treated with Vitamin E before being exposed to radical oxygen species via non-heme iron, then it will have ...


N-Linked Glycosylation Of The Bone Morphogenetic Protein Receptor Type 2 (Bmpr2) Enhances Ligand Binding, Jonathan W. Lowery Ph.D., Jose M Amich, Alex Andonian, Vicki Rosen Aug 2014

N-Linked Glycosylation Of The Bone Morphogenetic Protein Receptor Type 2 (Bmpr2) Enhances Ligand Binding, Jonathan W. Lowery Ph.D., Jose M Amich, Alex Andonian, Vicki Rosen

Faculty Publications and Research

The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate downstream transcription factors. It is well established that a single BMP receptor may bind multiple BMP ligands with varying affinity, and this has been largely attributed to conformation at the amino acid level. However, all three type 2 BMP receptors (BMPR2, ACVR2A/B) contain consensus N-glycosylation sites in their extracellular domains (ECDs), which could play a role in modulating interaction with ligand. Here, we show a ...


Abnormal Trafficking Of Endogenously Expressed Bmpr2 Mutant Allelic Products In Patients With Heritable Pulmonary Arterial Hypertension, Andrea L Frump, Jonathan W. Lowery Ph.D., Rizwan Hamid, Eric D Austin, Mark De Caestecker Jan 2013

Abnormal Trafficking Of Endogenously Expressed Bmpr2 Mutant Allelic Products In Patients With Heritable Pulmonary Arterial Hypertension, Andrea L Frump, Jonathan W. Lowery Ph.D., Rizwan Hamid, Eric D Austin, Mark De Caestecker

Faculty Publications and Research

More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). More severe clinical outcomes occur in patients with BMPR2 mutations by-passing nonsense-mediated mRNA decay (NMD negative mutations). These comprise 40% of HPAH mutations and are predicted to express BMPR2 mutant products. However expression of endogenous NMD negative BMPR2 mutant products and their effect on protein trafficking and signaling function have never been described. Here, we characterize the expression and trafficking of an HPAH-associated NMD negative BMPR2 mutation that results in an in-frame deletion of BMPR2 EXON2 ...