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Synergy Between Insulin-Like Growth Factor-I (Igf-I) E-Peptides And Igf-I Signaling Alters Growth In Skeletal Muscle, Becky Kathleen Brisson
Publicly Accessible Penn Dissertations
Insulin-like growth factor-I (IGF-I) is a potent growth factor that regulates and promotes growth in many types of cells and tissues, including skeletal muscle. The igf1 gene encodes mature IGF-I and a carboxy-terminal extension called the E-peptide. In rodents, alternative splicing and post-translational processing produce two E-peptides (EA and EB). The mature IGF-I produced by both isoforms is identical, while EA and EB share less than 50% homology. EB has been studied extensively and has been reported to promote cell proliferation and migration independently of IGF-I and its receptor (IGF-IR) in culture, but the mechanism by which EB causes these ...