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Physiology

GSBS Dissertations and Theses

Centrioles

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Full-Text Articles in Cell Biology

Roles Of The Mother Centriole Appendage Protein Cenexin In Microtubule Organization During Cell Migration And Cell Division: A Dissertation, Hui-Fang Hung Aug 2016

Roles Of The Mother Centriole Appendage Protein Cenexin In Microtubule Organization During Cell Migration And Cell Division: A Dissertation, Hui-Fang Hung

GSBS Dissertations and Theses

Epithelial cells are necessary building blocks of the organs they line. Their apicalbasolateral polarity, characterized by an asymmetric distribution of cell components along their apical-basal axis, is a requirement for normal organ function. Although the centrosome, also known as the microtubule organizing center, is important in establishing cell polarity the mechanisms through which it achieves this remain unclear. It has been suggested that the centrosome influences cell polarity through microtubule cytoskeleton organization and endosome trafficking. In the first chapter of this thesis, I summarize the current understanding of the mechanisms regulating cell polarity and review evidence for the role of ...


A Tale Of Two Projects: Basis For Centrosome Amplification After Dna Damage And Practical Assessment Of Photodamage In Live-Cell Imaging: A Dissertation, Stephen Douthwright Apr 2015

A Tale Of Two Projects: Basis For Centrosome Amplification After Dna Damage And Practical Assessment Of Photodamage In Live-Cell Imaging: A Dissertation, Stephen Douthwright

GSBS Dissertations and Theses

This thesis comprises two separate studies that focus on the consequences of cellular damage. The first investigates the effects of DNA damage on centriole behavior and the second characterizes phototoxicity during live-cell imaging.

Cancer treatments such as ionizing radiation and/or chemotherapeutic DNA damaging agents are intended to kill tumor cells, but they also damage normal proliferating cells. Although centrosome amplification after DNA damage is a well-established phenomenon for transformed cells, it is not fully understood in untransformed cells. The presence of extra centrosomes in normal cell populations raises the chances of genomic instability, thus posing additional threats to patients ...