Articles 1 - 1 of 1
Full-Text Articles in Cell Biology
Morphogenetic Requirements For Embryo Patterning And The Generation Of Stem Cell-Derived Mice: A Dissertation, Yeonsoo Yoon
GSBS Dissertations and Theses
Cell proliferation and differentiation are tightly regulated processes required for the proper development of multi-cellular organisms. To understand the effects of cell proliferation on embryo patterning in mice, we inactivated Aurora A, a gene essential for completion of the cell cycle. We discovered that inhibiting cell proliferation leads to different outcomes depending on the tissue affected. If the epiblast, the embryonic component, is compromised, it leads to gastrulation failure. However, when Aurora A is inactivated in extra-embryonic tissues, mutant embryos fail to properly establish the anteroposterior axis. Ablation of Aurora A in the epiblast eventually leads to abnormal embryos composed ...