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Full-Text Articles in Cell Biology

N-Linked Glycosylation Of The Bone Morphogenetic Protein Receptor Type 2 (Bmpr2) Enhances Ligand Binding, Jonathan W. Lowery Ph.D., Jose M Amich, Alex Andonian, Vicki Rosen Aug 2014

N-Linked Glycosylation Of The Bone Morphogenetic Protein Receptor Type 2 (Bmpr2) Enhances Ligand Binding, Jonathan W. Lowery Ph.D., Jose M Amich, Alex Andonian, Vicki Rosen

Faculty Publications and Research

The bone morphogenetic protein (BMP) signaling pathway is essential for normal development and tissue homeostasis. BMP signal transduction occurs when ligands interact with a complex of type 1 and type 2 receptors to activate downstream transcription factors. It is well established that a single BMP receptor may bind multiple BMP ligands with varying affinity, and this has been largely attributed to conformation at the amino acid level. However, all three type 2 BMP receptors (BMPR2, ACVR2A/B) contain consensus N-glycosylation sites in their extracellular domains (ECDs), which could play a role in modulating interaction with ligand. Here, we show a ...


The Role Of Integrin Mediated Adhesion And Signaling During Xenopus Retinal Development , Ming Li Jan 2003

The Role Of Integrin Mediated Adhesion And Signaling During Xenopus Retinal Development , Ming Li

Retrospective Theses and Dissertations

Integrins are the major family of cell adhesion receptors for extracellular matrix (ECM) components and are involved in cell-cell and cell-ECM adhesion. Integrins also participate in cytoskeletal rearrangements, activation of signal transductions, and co-regulation of growth factor activities.;In this dissertation, I have investigated the role of beta1 integrin-mediated adhesion and signaling during early Xenopus retinal development. First, I characterized the expression patterns of focal adhesion associated proteins, beta1 integrin, talin, vinculin, paxillin and phosphotyrosine in retinal glial cell line XR1 and in the developing Xenopus retina. These proteins are colocalized at focal adhesions located at the termini of F-actin ...


Nitric Oxide In Astrocyte-Neuron Signaling , Nianzhen Li Jan 2002

Nitric Oxide In Astrocyte-Neuron Signaling , Nianzhen Li

Retrospective Theses and Dissertations

Astrocytes, a subtype of glial cell, have recently been shown to exhibit Ca2+ elevations in response to neurotransmitters. A Ca 2+ elevation can propagate to adjacent astrocytes as a Ca2+ wave, which allows an astrocyte to communicate with its neighbors. Additionally, glutamate can be released from astrocytes via a Ca2+ -dependent mechanism, thus modulating neuronal activity and synaptic transmission.;In this dissertation, I investigated the roles of another endogenous signal, nitric oxide (NO), in astrocyte-neuron signaling. First I tested if NO is generated during astrocytic Ca2+ signaling by imaging NO in purified murine cortical astrocyte cultures. Physiological concentrations of a ...