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Pharmacology

Anti-inflammatory

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Full-Text Articles in Cell Biology

Echinacea Species And Alkamides Inhibit Prostaglandin E2 Production In Raw264.7 Mouse Macrophage Cells, Carlie A. Lalone, Kimberly D.P. Hammer, Lankun Wu, Jaehood Bae, Norma Leyva, Yi Liu, Avery K.S. Solco, George A. Kraus, Patricia A. Murphy, Eve S. Wurtele, Ok-Kyung Kim, Kwon Ii Seo, Mark P. Widrlechner, Diane F. Birt Jan 2007

Echinacea Species And Alkamides Inhibit Prostaglandin E2 Production In Raw264.7 Mouse Macrophage Cells, Carlie A. Lalone, Kimberly D.P. Hammer, Lankun Wu, Jaehood Bae, Norma Leyva, Yi Liu, Avery K.S. Solco, George A. Kraus, Patricia A. Murphy, Eve S. Wurtele, Ok-Kyung Kim, Kwon Ii Seo, Mark P. Widrlechner, Diane F. Birt

Food Science and Human Nutrition Publications

Inhibition of prostaglandin E2 (PGE2) production in lipopolysaccharide-stimulated RAW264.7 mouse macrophage cells was assessed with an enzyme immunoassay following treatments with Echinacea extracts or synthesized alkamides. Results indicated that ethanol extracts diluted in media to a concentration of 15 μg/mL from E. angustifolia, E. pallida, E. simulata, and E. sanguinea significantly inhibited PGE2 production. In further studies, PGE2 production was significantly reduced by all synthesized alkamides assayed at 50 μM, by Bauer alkamides 8, 12A analogue, and 14, Chen alkamide 2, and Chen alkamide 2 analogue at 25 μM and by Bauer alkamide 14 ...