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Phosphoproteomic Characterization Of Glycogen Synthase Kinase-3, Mansi Shinde
Publicly Accessible Penn Dissertations
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed kinase that acts as a critical regulator of many signaling pathways. These pathways, when dysregulated, have been implicated in many human diseases, including bipolar disorder (BD), cancer, and diabetes. Over 100 putative GSK-3 substrates have been reported, based on direct kinase assays or genetic and pharmacological manipulation of GSK-3, in diverse cell types. Many more have been predicted based upon on the prevalence of the GSK-3 consensus sequence. As a result, there remains an unclear picture of the complete GSK-3 phosphoproteome. We have therefore used a large-scale mass spectrometry approach ...