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Full-Text Articles in Cell Biology
Effect Of Increased Ratio Of Butyrate To Physiological Concentrations Of Acetate And Propionate On Intestinal Integrity And Il-8 Secretion In Caco-2 Cells, Nidhi Shah
Graduate Theses and Dissertations
Background: Inflammatory bowel diseases (IBD) are a growing global health problem. Current pharmacological therapies are not effective in all IBD patients, tend to cause side effects and in some cases lose effectiveness when used for a prolonged period of time. Hence, there is a need to develop dietary interventions that are safe and be applicable to all. Chronic inflammation of the gut could be combated by increasing the consumption of dietary fiber which would lead to an increased butyrate production in the colon. Butyrate has been shown to improve intestinal integrity and suppress the secretion of pro-inflammatory cytokine, IL-8 – which ...