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Nutrition

Wayne State University Dissertations

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Desensitization Of Basal Cell Carcinoma To The Anti-Tumoral Effect Of Vitamin D, Rawia Khasawneh Jan 2013

Desensitization Of Basal Cell Carcinoma To The Anti-Tumoral Effect Of Vitamin D, Rawia Khasawneh

Wayne State University Dissertations

The relationship between Vitamin D and NMSC is not very clear. Most of human studies in literature in regards to vitamin D and NMSC are epidemiological which are inconsistent and inconclusive. Mechanistic studies about BCC are few, and mostly are animal models or cell cultures. The main goal for this study is to interpret the impact of vitamin D status on the onset and progression and possibly treatment of basal cell carcinoma. Three tissue samples were collected from BCC patients (Cancer, Proximal, and Distal), and from cancer-free individuals from southeast Michigan. This study design helps identifying alterations in the genetic ...