Open Access. Powered by Scholars. Published by Universities.®

Cell Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 2 of 2

Full-Text Articles in Cell Biology

Effect Of Increased Ratio Of Butyrate To Physiological Concentrations Of Acetate And Propionate On Intestinal Integrity And Il-8 Secretion In Caco-2 Cells, Nidhi Shah Jan 2018

Effect Of Increased Ratio Of Butyrate To Physiological Concentrations Of Acetate And Propionate On Intestinal Integrity And Il-8 Secretion In Caco-2 Cells, Nidhi Shah

Graduate Theses and Dissertations

Background: Inflammatory bowel diseases (IBD) are a growing global health problem. Current pharmacological therapies are not effective in all IBD patients, tend to cause side effects and in some cases lose effectiveness when used for a prolonged period of time. Hence, there is a need to develop dietary interventions that are safe and be applicable to all. Chronic inflammation of the gut could be combated by increasing the consumption of dietary fiber which would lead to an increased butyrate production in the colon. Butyrate has been shown to improve intestinal integrity and suppress the secretion of pro-inflammatory cytokine, IL-8 – which ...


Investigating The Dual Roles Of Stra6 In Cell Signaling And Vitamin A Trafficking, Christina Elaine Schulte Jan 2012

Investigating The Dual Roles Of Stra6 In Cell Signaling And Vitamin A Trafficking, Christina Elaine Schulte

Graduate Theses and Dissertations

The long-term goal of the present study is to understand how cancer incidence and progression can be reduced through the optimization of vitamin A trafficking and signaling in tissues prone to tumor development. However, little is known about vitamin A uptake, transport, or signaling in epithelial cells prone to tumorigenesis. Retinol, the major circulating retinoid, is delivered to peripheral tissues in complex with retinol binding protein (RBP). Recently, a retinoic acid responsive protein with no previous known biological function, STRA6, has been identified as an essential transmembrane receptor that mediates retinol uptake in retinal epithelial cells. More recently, STRA6 was ...