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Cancer Biology Commons

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P53

Undergraduate Honors Theses

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Full-Text Articles in Cancer Biology

The Bbc3 Antisense Intragenic Transcript, Bait, Contributes To Puma Expression By A P53-Autonomous Mechanism, Nicole C. Michael Jan 2015

The Bbc3 Antisense Intragenic Transcript, Bait, Contributes To Puma Expression By A P53-Autonomous Mechanism, Nicole C. Michael

Undergraduate Honors Theses

p53 is a tumor suppressor protein which orchestrates cell cycle arrest or apoptosis to prevent the hyperproliferation of cells which could lead to cancer. However, when p53 is inactivated, which happens in over 50% of cancers, it fails to induce PUMA, a potent apoptotic protein. Loss of PUMA makes cancer cells less likely to undergo apoptosis upon stress stimuli. Recent GRO-seq data revealed unique antisense transcription initiated 6kb into the PUMA locus, creating a small noncoding RNA transcript dubbed BAIT (BBC3 antisense intragenic transcript). This project focused on understanding the expression and function of BAIT, which we hypothesized could modulate ...