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P53

GSBS Dissertations and Theses

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Defining The Roles Of P300/Cbp (Creb Binding Protein) And S5a In P53 Polyubiquitination, Degradation And Dna Damage Responses: A Dissertation, Dingding Shi Jan 2010

Defining The Roles Of P300/Cbp (Creb Binding Protein) And S5a In P53 Polyubiquitination, Degradation And Dna Damage Responses: A Dissertation, Dingding Shi

GSBS Dissertations and Theses

p53, known as the “guardian of the genome”, is the most well-characterized tumor suppressor gene. The central role of p53 is to prevent genome instability. p53 is the central node in an incredibly elaborate genome defense network for receiving various input stress signals and controlling diverse cellular responses. The final output of this network is determined not only by the p53 protein itself, but also by other p53 cooperating proteins.

p300 and CBP (CREB-Binding Protein) act as multifunctional regulators of p53 via acetylase and ubiquitin ligase activities. Prior work in vitro has shown that the N-terminal 595 aa of p300 ...