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Cancer Biology Commons

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Cancer

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Articles 121 - 141 of 141

Full-Text Articles in Cancer Biology

Genetics And Cancer, Sachin Puri Jan 2012

Genetics And Cancer, Sachin Puri

A with Honors Projects

Genes' effect in body and relationship with cancer. Role in cell cycle and angiogenesis.


The Effects Of Cancer, Mara Lapayne Jan 2012

The Effects Of Cancer, Mara Lapayne

A with Honors Projects

I chose to do a project related to cancer for my Painting 1 class. Using oil paint, I wanted to create a more symbolic representation of cancer. So I made a cloud-like, cancerous mass with streaks of chaotic color swirling around a central face. The face represents any person affected by cancer and has had to “shut down” their emotions in order to function. I wanted the skin texture to be almost metallic as if it is metal armor or robotic-like, to support the idea of “shutting down” one’s emotions. The blank expression also portrays this idea.


Chemotherapy: The Physiological Cost Of A Cure, Megan Ellis Jan 2012

Chemotherapy: The Physiological Cost Of A Cure, Megan Ellis

A with Honors Projects

This project focuses on the common long term side effects of cancer treatments, apart from cure. In addition to physiological function changes, it focuses on the chemical composition of chemotherapy drugs.


Prl-1’S Inhibition Of Drosophila Melanogaster Cell Growth Is Dependent On The Caax Membrane Localization Domain, Bryce Bunn Jan 2012

Prl-1’S Inhibition Of Drosophila Melanogaster Cell Growth Is Dependent On The Caax Membrane Localization Domain, Bryce Bunn

Summer Research

The human body exhibits a spectacular collection of cells, integrated with seemingly infinite communication techniques and control mechanisms. Cancer’s disastrous influence on this complex system proves difficult to map. The shotgun clinical trial testing of human cancers has provided a feast of proteins suspected of encouraging cancerous cell behavior. One, Phosphatase of Regenerating Liver protein-1 (PRL-1), has been found to encourage cancerous growth while localizing in a variety of subcellular locations within metastasizing human tumor cells. However, PRL-1 has also been found to act as a tumor suppressor while localizing to the cell membrane in mammalian and insect models ...


Evaluation Of Daily Oral Kinase Inhibitors In Pediatric Spnet Tumor Xenografts, Greg Heinicke Jan 2012

Evaluation Of Daily Oral Kinase Inhibitors In Pediatric Spnet Tumor Xenografts, Greg Heinicke

Undergraduate Honors Theses

Throughout the human body cells grow and die at different rates. Each tissue has specific cellular requirements that define the growth and death of its cells. For example red blood cells are replaced frequently whereas brain cells slowly die with age and are not replaced. Cancer comes from a fundamental breakdown in the regulation of growth. These new growing cells reach a point when they are too abundant. When they have surpassed the body's need for new cells, they form large masses called tumors. Tumors are deadly when they become malignant. Malignant cells have the ability to invade and ...


Role Of Hypoxia And Glycolysis In The Development Of Multi-Drug Resistance In Human Tumor Cells And The Establishment Of An Orthotopic Multi-Drug Resistant Tumor Model In Nude Mice Using Hypoxic Pre-Conditioning, Lara Milane, Zhenfeng Duan, Mansoor M. Amiji Sep 2011

Role Of Hypoxia And Glycolysis In The Development Of Multi-Drug Resistance In Human Tumor Cells And The Establishment Of An Orthotopic Multi-Drug Resistant Tumor Model In Nude Mice Using Hypoxic Pre-Conditioning, Lara Milane, Zhenfeng Duan, Mansoor M. Amiji

Mansoor M. Amiji

Background The development of multi-drug resistant (MDR) cancer is a significant challenge in the clinical treatment of recurrent disease. Hypoxia is an environmental selection pressure that contributes to the development of MDR. Many cancer cells, including MDR cells, resort to glycolysis for energy acquisition. This study aimed to explore the relationship between hypoxia, glycolysis, and MDR in a panel of human breast and ovarian cancer cells. A second aim of this study was to develop an orthotopic animal model of MDR breast cancer. Methods Nucleic and basal protein was extracted from a panel of human breast and ovarian cancer cells ...


Developmental Deregulation And Tumorigenesis Inhibition In 14-3-3zeta Knockout Mouse, Jun Yang Aug 2011

Developmental Deregulation And Tumorigenesis Inhibition In 14-3-3zeta Knockout Mouse, Jun Yang

UT GSBS Dissertations and Theses (Open Access)

Cancer is second leading cause of death in the United States. Improving cancer care through patient care, research, education and prevention not only saves lives, but reduces health care cost as well. Breast cancer is the most leading cause of cancer incidence and cancer related death in women of the United States. 14-3-3s are a family of conserved proteins ubiquitously expressed in all eukaryotic organisms. They form complexes with hundreds of proteins by binding to specific phospho-serine/threonine containing motifs. In this way they regulate a variety of cellular processes and are involved in many human diseases especially cancer to ...


Zinc Oxide Nanoparticles As Potential Novel Anticancer Therapies, Janet C. Layne May 2011

Zinc Oxide Nanoparticles As Potential Novel Anticancer Therapies, Janet C. Layne

Boise State University Theses and Dissertations

Nanoparticles (NP) are increasingly being recognized for their utility in the field of medicine, including use as drug carriers and imaging tools. We demonstrated that ZnO NP preferentially kill cancerous cells of the T cell lineage, and extended this research to evaluate other cells types, including normal and malignant B cells, and normal and malignant breast and prostate epithelial cells. Preferential ZnO nanoparticle cytotoxicity occurred for multiple types of cancer cells, but was most pronounced for non-adherent cells of hematopoietic lineage. Normal T and B lymphocytes showed the greatest resistance to NP toxicity, followed by normal breast epithelial cells, and ...


Atm Signaling To Tsc2: Mechanisms And Implications For Cancer Therapy, Angela Alexander May 2011

Atm Signaling To Tsc2: Mechanisms And Implications For Cancer Therapy, Angela Alexander

UT GSBS Dissertations and Theses (Open Access)

Ataxia telangiectasia mutated (ATM) is a critical component of the cellular response to DNA damage, where it acts as a damage sensor, and signals to a large network of proteins which execute the important tasks involved in responding to the damage, namely inducing cell cycle checkpoints, inducing DNA repair, modulating transcriptional responses, and regulating cell death pathways if the damage cannot be repaired faithfully. We have now discovered that an additional novel component of this ATM-dependent damage response involves induction of autophagy in response to oxidative stress. In contrast to DNA damage-induced ATM activation however, oxidative stress induced ATM, occurs ...


Modeling Measurement Error In Tumor Characterization Studies, Cyril Rakovski, Daniel J. Weisenberger, Paul Marjoram, Peter W. Laird, Kimberly D. Siegmund Jan 2011

Modeling Measurement Error In Tumor Characterization Studies, Cyril Rakovski, Daniel J. Weisenberger, Paul Marjoram, Peter W. Laird, Kimberly D. Siegmund

Mathematics, Physics, and Computer Science Faculty Articles and Research

Background: Etiologic studies of cancer increasingly use molecular features such as gene expression, DNA methylation and sequence mutation to subclassify the cancer type. In large population-based studies, the tumor tissues available for study are archival specimens that provide variable amounts of amplifiable DNA for molecular analysis. As molecular features measured from small amounts of tumor DNA are inherently noisy, we propose a novel approach to improve statistical efficiency when comparing groups of samples. We illustrate the phenomenon using the MethyLight technology, applying our proposed analysis to compare MLH1 DNA methylation levels in males and females studied in the Colon Cancer ...


Characterizing The Role Of Dna Repair Proteins In Telomere Length Regulation And Maintenance: Fanconi Anemia Complementation Group C Protein And 8-Oxoguanine Dna Glycosylase, David Beomjin Rhee Aug 2010

Characterizing The Role Of Dna Repair Proteins In Telomere Length Regulation And Maintenance: Fanconi Anemia Complementation Group C Protein And 8-Oxoguanine Dna Glycosylase, David Beomjin Rhee

Doctoral Dissertations

Telomeres are the chromosome end structures consisting of telomere-associated proteins and short tandem repeat sequences, TTAGGG, in humans and mice. Telomeres prevent chromosome termini from being recognized as broken DNA ends. The structural integrity of DNA including telomeres is constantly threatened by a variety of DNA damaging agents on a daily basis. To counteract the constant threats from DNA damage, organisms have developed a number of DNA repair pathways to ensure that the integrity of genome remains intact. A number of DNA repair proteins localize to telomeres and contribute to telomere maintenance; however, it is still unclear as to what ...


The Role Of The Transcription Factor Atf4iin Tumor Progression Under Nutrient Deprivation And Hypoxia, Jiangbin Ye May 2010

The Role Of The Transcription Factor Atf4iin Tumor Progression Under Nutrient Deprivation And Hypoxia, Jiangbin Ye

Publicly Accessible Penn Dissertations

The transcription factor ATF4 regulates the expression of mRNAs involved in amino acid metabolism, redox homeostasis and ER stress responses. Its overexpression in human solid tumors suggests an important role in tumor biology. Here we report that inhibition of ATF4 expression blocks proliferation and survival of transformed cells, despite an initial activation of cytoprotective macroautophagy. Knockdown of ATF4 significantly reduced the levels of asparagine synthetase (ASNS). Overexpression of ASNS or supplementation of asparagine in trans, reverses the proliferation block and increases survival in ATF4 knockdown cells. Both amino acid and glucose deprivation, stresses found in solid tumors, activate the upstream ...


Functional Analysis Of Chromodomain Helicase Dna Binding Protein 2(Chd2) Mediated Genomic Stability, Sangeetha Rajagopalan May 2010

Functional Analysis Of Chromodomain Helicase Dna Binding Protein 2(Chd2) Mediated Genomic Stability, Sangeetha Rajagopalan

Doctoral Dissertations

Histone modifying enzymes and chromatin remodeling complexes play an important regulatory role in chromatin dynamics that dictate the interaction of regulatory factors involved in processes such as DNA replication, recombination, repair and transcription, with DNA template. The CHD (Chromodomain Helicase DNA Binding Protein) family of proteins is known to be involved in the regulation of gene expression, recombination and chromatin remodeling via their chromatin specific interactions and activities. Phenotypic analysis of the Chd2 mutant mouse model developed by our laboratory indicates that the Chd2 protein plays a critical role in tumor suppression as the heterozygous mutant mice develop spontaneous lymphomas ...


Analysis Of Primary Risk Factors For Oral Cancer From Us States With Increasing Rates, Anthony Bunnell, Nathan Pettit, Nicole Reddout, Kanika Sharma, Susan O'Malley, Michelle Chino, Karl Kingsley Feb 2010

Analysis Of Primary Risk Factors For Oral Cancer From Us States With Increasing Rates, Anthony Bunnell, Nathan Pettit, Nicole Reddout, Kanika Sharma, Susan O'Malley, Michelle Chino, Karl Kingsley

Public Health Faculty Publications

Objectives

To examine the primary risk factor for oral cancer in the US, smoking and tobacco use, among the specific US states that experienced short-term increases in oral cancer incidence and mortality.

Methods

Population-based data on oral cancer morbidity and mortality in the US were obtained from the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) database for analysis of recent trends. Data were also obtained from the Centers for Disease Control and Prevention (CDC) Behavioral Risk Factor Surveillance System (BRFSS) to measure current and former trends of tobacco usage. To comprehensive measures of previous state tobacco ...


Regulation Of Crbp1 In Mammary Epithelial Cells, Stacy L. Pease Jan 2010

Regulation Of Crbp1 In Mammary Epithelial Cells, Stacy L. Pease

Masters Theses 1911 - February 2014

Breast cancer is the second leading cause of death of women in the United States, warranting further investigation into preventative therapies. It has been well documented that early pregnancy results in a lifetime decreased risk of breast cancer in humans and mounting evidence suggests that the retinoic acid pathway may play an important role in this protective effect. Cellular retinol binding protein-1 (CRBP1) is an essential component of the retinoic acid pathway and we propose that it plays an important role in pregnancy-induced protection against breast cancer. In order to investigate the role of CRBP1 in parity-induced protection against breast ...


Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro Apr 2008

Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro

Articles

BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Clinical trials that combine Treg depletion with tumor vaccination are underway to determine whether transient Treg depletion can enhance anti-tumor immune responses and improve long term survival in cancer patients. FINDINGS: Using a syngeneic intracrabial glioblastoma (GBM) mouse model we show that systemic depletion of Tregs 15 days after tumor implantation using PC61 resulted in a decrease in Tregs ...


Fighting Demons, Fighting Cancer, Ethan Helm Mar 2008

Fighting Demons, Fighting Cancer, Ethan Helm

Eukaryon

Demons. I’m surrounded by demons. To my left, soul-draining succubi shoot balls of magic, to the right stand acid-flinging Cerberuses, and straight ahead, gigantic, fire-breathing balrogs lurk ominously. First I charge the succubi, killing them quickly with a barrage of Level 20 fireballs. Next, I take the Cerberuses using the same technique. The balrogs, however, are immune to fire. I push F4 to change my spell to chain lightning and electrocute the spawns of Satan. Now, on to Lazarus, the teleporting super demon. I’ll get him though, for I can teleport too!


Identification Of Key Binding Partners Of Elongin C, Allie Maffit Apr 2006

Identification Of Key Binding Partners Of Elongin C, Allie Maffit

Life and Environmental Sciences Undergraduate Theses

Cancer is the second leading cause of death in the United States. Prostate cancer affects one in seven men in the United States. Thus, prostate cancer provides a very serious healthy threat to men in the United States. Unfortunately, not much is known as to how normal prostate cells are transformed into a cancerous state, or how once transformed remain in the cancerous state. A study preformed by Porkka et. al in 2002 revealed that Elongin C is over expressed in prostate cancer cell lines. I hypothesize that over expression of Elongin C could inappropriately stabilize or destabilize key proteins ...


Nf-Kb: A Novel Therapeutic Target For Cancer, Arun George Paul Jan 2005

Nf-Kb: A Novel Therapeutic Target For Cancer, Arun George Paul

Eukaryon

No abstract provided.


Outpatient Administration Of Paclitaxel, Siu Fun Wong Jan 1994

Outpatient Administration Of Paclitaxel, Siu Fun Wong

Pharmacy Faculty Articles and Research

Paclitaxel (Taxol®, Bristol-Meyers Squibb), anti neoplastic agent made from the bark of the Pacific yew tree, is undoubtedly one of the most exciting agents to be evaluated over the past decade. Paclitaxel has demonstrated significant promise against ovarian and metastatic breast cancer, and appears to be the most effective single agent to date for non-small-cell lung cancer in trials conducted by Eastern Cooperative Oncology Group (ECOG).


Old Remedies In The Biotechnology Age: Moore V. Regents, Michelle J. Burke, Victoria M. Schmidt Jun 1992

Old Remedies In The Biotechnology Age: Moore V. Regents, Michelle J. Burke, Victoria M. Schmidt

RISK: Health, Safety & Environment (1990-2002)

The California Supreme Court, by excluding a potential remedy, has eliminated many concerns generated by a lower court decision resolving rights to the cell line derived from John Moore's spleen. Yet, the Supreme Court gave little attention to remedies that remain. The authors argue that a constructive trust, a remedy of considerable vintage and great flexibility, could be applied to achieve a just result in such circumstances without affecting the biotechnology world at large.