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Cancer Biology Commons

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Full-Text Articles in Cancer Biology

Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro Apr 2008

Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro

Articles

BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Clinical trials that combine Treg depletion with tumor vaccination are underway to determine whether transient Treg depletion can enhance anti-tumor immune responses and improve long term survival in cancer patients. FINDINGS: Using a syngeneic intracrabial glioblastoma (GBM) mouse model we show that systemic depletion of Tregs 15 days after tumor implantation using PC61 resulted in a decrease in Tregs ...


Fighting Demons, Fighting Cancer, Ethan Helm Mar 2008

Fighting Demons, Fighting Cancer, Ethan Helm

Eukaryon

Demons. I’m surrounded by demons. To my left, soul-draining succubi shoot balls of magic, to the right stand acid-flinging Cerberuses, and straight ahead, gigantic, fire-breathing balrogs lurk ominously. First I charge the succubi, killing them quickly with a barrage of Level 20 fireballs. Next, I take the Cerberuses using the same technique. The balrogs, however, are immune to fire. I push F4 to change my spell to chain lightning and electrocute the spawns of Satan. Now, on to Lazarus, the teleporting super demon. I’ll get him though, for I can teleport too!