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Cancer Biology Commons

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Full-Text Articles in Cancer Biology

Analysis Of Integrin Α6Β4 Function In Breast Carcinoma: A Dissertation, Kristin D. Gerson Apr 2012

Analysis Of Integrin Α6Β4 Function In Breast Carcinoma: A Dissertation, Kristin D. Gerson

GSBS Dissertations and Theses

The development and survival of multicellular organisms depends upon the ability of cells to move. Embryogenesis, immune surveillance, wound healing, and metastatic disease are all processes that necessitate effective cellular locomotion. Central to the process of cell motility is the family of integrins, transmembrane cell surface receptors that mediate stable adhesions between cells and their extracellular environment. Many human diseases are associated with aberrant integrin function. Carcinoma cells in particular can hijack integrins, harnessing their mechanical and signaling potential to propagate cell invasion and metastatic disease, one example being integrin α6β4. This integrin, often referred to simply as β4, is ...


Localization Of Insulin Receptor Substrate-2 In Breast Cancer: A Dissertation, Jennifer L. Clark Mar 2012

Localization Of Insulin Receptor Substrate-2 In Breast Cancer: A Dissertation, Jennifer L. Clark

GSBS Dissertations and Theses

The insulin-like growth factor-1 receptor (IGF-1R) and many of its downstream signaling components have long been implicated in tumor progression and resistance to therapy. The insulin receptor substrate-1 (IRS-1) and IRS-2 adaptor proteins are two of the major downstream signaling intermediates of the IGF-1R. Despite their considerable homology, previous work in our lab and others has shown that IRS-1 and IRS-2 play divergent roles in breast cancer cells. Signaling through IRS-1 promotes cell proliferation, whereas signaling through IRS-2 promotes cell motility and invasion, as well as glycolysis. Moreover, using a mouse model of mammary tumorigenesis, our lab demonstrated that IRS-2 ...