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Cancer Biology Commons

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2012

Botswana-UPenn Scholarly Publications

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Full-Text Articles in Cancer Biology

Characterization Of The Ossn Microbiome In Hiv-1 Infected Patients, Kenneth O. Simbiri, Erle S. Robertson May 2012

Characterization Of The Ossn Microbiome In Hiv-1 Infected Patients, Kenneth O. Simbiri, Erle S. Robertson

Botswana-UPenn Scholarly Publications

Purpose: Ocular surface squamous neoplasia (OSSN) is a rare cancer previously seen in elderly men. In Botswana there is an increase in OSSN and pterygia among young HIV-1 infected patients. Factors that determine the course of this cancer have not been characterized. Recent studies identified HPV, EBV, KSHV, HSV-1/2, and CMV in patient samples. We now characterize the microbiome associated with the disease that may contribute to its course.

Results: Pyrosequencing identified viruses, bacteria, fungus and parasites. Analysis of shotgun cloning sequences showed a majority of infectious agents identified by pyrosequencing.

Conclusion: HIV patients with OSSN in Botswana are ...