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Cancer Biology Commons

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Full-Text Articles in Cancer Biology

Rok And Rac Mediation Of Prl-1 Function In The Wings Of Drosophila Melanogaster, Rosemary Dinkins May 2012

Rok And Rac Mediation Of Prl-1 Function In The Wings Of Drosophila Melanogaster, Rosemary Dinkins

Honors Program Theses

By the time a cancer metastasizes it has reached its most deadly stage. It therefore is essential that the underpinning mechanisms promoting metastasis are understood. Phosphatases of regenerating liver (PRL) have been repeatedly connected to cancer metastasis when overexpressed. However, little is yet known about the normal PRL function and biological pathways let alone the PRL pathway promoting metastasis. The current study explores the relationship between PRL-1 and two other genes, ROK and Rac,that have also been implicated in cell migration and metastasis. Increased PRL-1 function in conjunction with increased or decreased Rac function was forced to the dorsal ...


Prl-1’S Inhibition Of Drosophila Melanogaster Cell Growth Is Dependent On The Caax Membrane Localization Domain, Bryce Bunn Jan 2012

Prl-1’S Inhibition Of Drosophila Melanogaster Cell Growth Is Dependent On The Caax Membrane Localization Domain, Bryce Bunn

Summer Research

The human body exhibits a spectacular collection of cells, integrated with seemingly infinite communication techniques and control mechanisms. Cancer’s disastrous influence on this complex system proves difficult to map. The shotgun clinical trial testing of human cancers has provided a feast of proteins suspected of encouraging cancerous cell behavior. One, Phosphatase of Regenerating Liver protein-1 (PRL-1), has been found to encourage cancerous growth while localizing in a variety of subcellular locations within metastasizing human tumor cells. However, PRL-1 has also been found to act as a tumor suppressor while localizing to the cell membrane in mammalian and insect models ...