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Cancer Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

1998

1-Methyl-3-isobutylxanthine; 1-Phosphatidylinositol 3-Kinase; 3',5'-Cyclic-AMP Phosphodiesterases; Antibodies; Antigens, Surface; Breast Neoplasms; Chemotaxis; Culture Media, Conditioned; Cyclic AMP; Female; Fibroblasts; Forskolin; Humans; Integrin alpha6beta4; Integrins; Kinetics; Lysophospholipids; Neoplasm Invasiveness; Phosphodiesterase Inhibitors; Pyrrolidinones; Rolipram; Signal Transduction; Tumor Cells, Cultured

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Full-Text Articles in Cancer Biology

Release Of Camp Gating By The Alpha6beta4 Integrin Stimulates Lamellae Formation And The Chemotactic Migration Of Invasive Carcinoma Cells, Kathleen L. O'Connor, Leslie M. Shaw, Arthur M. Mercurio Dec 1998

Release Of Camp Gating By The Alpha6beta4 Integrin Stimulates Lamellae Formation And The Chemotactic Migration Of Invasive Carcinoma Cells, Kathleen L. O'Connor, Leslie M. Shaw, Arthur M. Mercurio

Cancer Biology Publications and Presentations

The alpha6beta4 integrin promotes carcinoma in-vasion by its activation of a phosphoinositide 3-OH (PI3-K) signaling pathway (Shaw, L.M., I. Rabinovitz, H.H.-F. Wang, A. Toker, and A.M. Mercurio. Cell. 91: 949-960). We demonstrate here using MDA-MB-435 breast carcinoma cells that alpha6beta4 stimulates chemotactic migration, a key component of invasion, but that it has no influence on haptotaxis. Stimulation of chemotaxis by alpha6beta4 expression was observed in response to either lysophosphatidic acid (LPA) or fibroblast conditioned medium. Moreover, the LPA-dependent formation of lamellae in these cells is dependent upon alpha6beta4 expression. Both lamellae formation and chemotactic migration are ...