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Cancer Biology Commons

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Articles 1 - 4 of 4

Full-Text Articles in Cancer Biology

Regulation Of Alpha 6 Beta 1 Integrin Laminin Receptor Function By The Cytoplasmic Domain Of The Alpha 6 Subunit, Leslie M. Shaw, Arthur M. Mercurio Nov 1993

Regulation Of Alpha 6 Beta 1 Integrin Laminin Receptor Function By The Cytoplasmic Domain Of The Alpha 6 Subunit, Leslie M. Shaw, Arthur M. Mercurio

Cancer Biology Publications and Presentations

The alpha 6 beta 1 integrin is expressed on the macrophage surface in an inactive state and requires cellular activation with PMA or cytokines to function as a laminin receptor (Shaw, L. M., J. M. Messier, and A. M. Mercurio. 1990. J. Cell Biol. 110:2167-2174). In the present study, the role of the alpha 6 subunit cytoplasmic domain in alpha 6 beta 1 integrin activation was examined. The use of P388D1 cells, an alpha 6-integrin deficient macrophage cell line, facilitated this analysis because expression of either the alpha 6A or alpha 6B subunit cDNAs restores their activation responsive laminin ...


Concerted Control Of Multiple Histone Promoter Factors During Cell Density Inhibition Of Proliferation In Osteosarcoma Cells: Reciprocal Regulation Of Cell Cycle-Controlled And Bone-Related Genes, Fusinita M. I. Van Den Ent, Andre J. Van Wijnen, Thomas J. Last, Rita Bortell, Janet L. Stein, Jane B. Lian, Gary S. Stein May 1993

Concerted Control Of Multiple Histone Promoter Factors During Cell Density Inhibition Of Proliferation In Osteosarcoma Cells: Reciprocal Regulation Of Cell Cycle-Controlled And Bone-Related Genes, Fusinita M. I. Van Den Ent, Andre J. Van Wijnen, Thomas J. Last, Rita Bortell, Janet L. Stein, Jane B. Lian, Gary S. Stein

Open Access Articles

Cell density-induced growth inhibition of osteosarcoma cells (ROS 17/2.8) results in the shutdown of proliferation-specific histone H4 and H2B genes and the concomitant up-regulation of several osteoblast-related genes. In several respects, this reciprocal regulatory relationship is analogous to the proliferation/differentiation transition stage during development of the bone cell phenotype in normal diploid osteoblasts. Here, we comprehensively analyzed the promoter binding activities interfacing with key regulatory elements in the cell cycle-dependent histone and bone-specific osteocalcin genes. Similarly, we examined factors interacting with a series of general transcription regulatory elements that are present in a broad spectrum of promoters ...


Do All Programmed Cell Deaths Occur Via Apoptosis?, Sallie Smith Schneider, L.M. Schwartz, M.E.E Jones, B.A. Osborne Dec 1992

Do All Programmed Cell Deaths Occur Via Apoptosis?, Sallie Smith Schneider, L.M. Schwartz, M.E.E Jones, B.A. Osborne

Sallie W Smith Schneider

No abstract provided.


P53 Is Required For Radiation-Induced Apoptosis In Mouse Thymocytes, Sallie Smith Schneider, S.W. Lowe, E.M. Schmitt, B.A. Osborne Dec 1992

P53 Is Required For Radiation-Induced Apoptosis In Mouse Thymocytes, Sallie Smith Schneider, S.W. Lowe, E.M. Schmitt, B.A. Osborne

Sallie W Smith Schneider

No abstract provided.