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Cancer Biology Commons

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1988

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Articles 1 - 4 of 4

Full-Text Articles in Cancer Biology

Macrophage Interactions With Laminin: Pma Selectively Induces The Adherence And Spreading Of Mouse Macrophages On A Laminin Substratum, Arthur M. Mercurio, Leslie M. Shaw Nov 1988

Macrophage Interactions With Laminin: Pma Selectively Induces The Adherence And Spreading Of Mouse Macrophages On A Laminin Substratum, Arthur M. Mercurio, Leslie M. Shaw

Cancer Biology Publications and Presentations

The ability of thioglycollate (TG)-elicited mouse peritoneal macrophages to adhere to a laminin substratum has been studied. These cells do not adhere to laminin-coated (20 micrograms/ml) surfaces, but the addition of phorbol myristate acetate (PMA; 50 ng/ml) results in their rapid adherence and spreading on this substratum. TG-elicited and PMA-activated macrophages, however, can bind soluble laminin. Macrophages adhere to fibronectin-coated surfaces and tissue culture plastic without PMA stimulation, and PMA does not increase the number of cells that adhere to these surfaces. The predominant surface proteins that bind specifically to laminin-Sepharose exhibit an Mr of 67 and ...


Effects Of Implanted Phechromocytoma On T4/T8 Ratio Of T-Lymphocytes In New England Deaconess Hospital Rat, Christine Drivdahl Apr 1988

Effects Of Implanted Phechromocytoma On T4/T8 Ratio Of T-Lymphocytes In New England Deaconess Hospital Rat, Christine Drivdahl

Life and Environmental Sciences Undergraduate Theses

The effect of implanted pheochromocytoma on (1) blood pressure, (2) catecholamine concentration, and (3) T4 and T8 lymphocyte subsets in the rat (New England Deaconess Hospital strain) was studied. Blood pressure increased significantly. Catecholamine concentrations rose greatly after tumor implant, with dopamine showing the greatest increase. T4 percentages decreased slightly as compared to pre-implant percentages. T8 results could be divided into two subsets based on a definite increase or a definite decrease from pre-implant percentages. Finally, rats that showed an increase of T8 cells had significantly greater concentrations of dopamine (and, to a lesser extent, epinephrine and norepinephrine) than those ...


Laminin Receptors For Neurite Formation, H. K. Kleinman, Roy C. Ogle, F. B. Cannon, C. D. Little, T. M. Sweeney, L. Luckenbill-Edds Feb 1988

Laminin Receptors For Neurite Formation, H. K. Kleinman, Roy C. Ogle, F. B. Cannon, C. D. Little, T. M. Sweeney, L. Luckenbill-Edds

Medical Diagnostics & Translational Sciences Faculty Publications

Laminin, a basement membrane glycoprotein promotes both cell attachment and neurite outgrowth. Separate domains on laminin elicit these responses, suggesting that distinct receptors occur on the surface of cells. NG108-15 neuroblastoma-glioma cells rapidly extend long processes in the presence of laminin. We report here that 125I-labeled laminin specifically binds to these cells and to three membrane proteins of 67, 110, and 180 kDa. These proteins were isolated by affinity chromatography on laminin-Sepharose. The 67-kDa protein reacted with antibody to the previously characterized receptor for cell attachment to laminin. Antibodies to the 110-kDa and 180-kDa bands demonstrated that the 110-kDa protein ...


Policy For Identifying And Assessing The Health Risks Of Toxic Substances, Maine Bureau Of Health Feb 1988

Policy For Identifying And Assessing The Health Risks Of Toxic Substances, Maine Bureau Of Health

Maine Collection

Policy for Identifying and Assessing the Health Risks of Toxic Substances

by Norman T. Anderson, Environmental Toxicology Program, Division of Disease Control, Bureau of Health (February, 1988).

Contents: Section I: Introduction / Section II: Methods / Section III: Exposure Assessment / Section IV: Hazard Identification / Section V: Hazard Assessment / Section VI: Risk Characterization / List of Figures / List of Tables