Open Access. Powered by Scholars. Published by Universities.®

Cancer Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

1984

Pharmacology, Toxicology and Environmental Health

Articles 1 - 1 of 1

Full-Text Articles in Cancer Biology

The Cytotoxic And Kinetic Effects Of Asynchronous Cells Following The Administration Of Vincristine, Meri Firpo Apr 1984

The Cytotoxic And Kinetic Effects Of Asynchronous Cells Following The Administration Of Vincristine, Meri Firpo

Life and Environmental Sciences Undergraduate Theses

A growth curve was constructed for SCCVII-SF, a mouse squamous cell carcinoma cell line, in a culture of modified q-crle's medium. A toxicity curve was constructed for vincristine ,nd SCCVII-SF cells in the exponential phase of growth. Cells in mid-exponential phase were treated with a subtoxic level of vincristine for four hours. A count of mitotic cells was taken at intervals to determine whether vincristine caused a buildup of cells in mitosis after its removal. Results showed that cells continued to collect in mitosis for four hours after the removal of vincristine.