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Cancer Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

1984

Neoplasms

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Full-Text Articles in Cancer Biology

Glycolipids Of The Mouse Peritoneal Macrophage. Alterations In Amount And Surface Exposure Of Specific Glycolipid Species Occur In Response To Inflammation And Tumoricidal Activation, Arthur M. Mercurio, Gerald A. Schwarting, Phillips W. Robbins Oct 1984

Glycolipids Of The Mouse Peritoneal Macrophage. Alterations In Amount And Surface Exposure Of Specific Glycolipid Species Occur In Response To Inflammation And Tumoricidal Activation, Arthur M. Mercurio, Gerald A. Schwarting, Phillips W. Robbins

Cancer Biology Publications and Presentations

We have characterized the major glycolipid constituents of the mouse peritoneal macrophage, and have demonstrated that alterations in the amount and in the accessibility of specific glycolipid species to galactose oxidase/NaB3H4 labeling, an indicator of glycolipid surface exposure, occur in response to inflammation and as a consequence of activation to a tumoricidal state. The key findings are: (a) Asialo GM1, a major neutral glycolipid constituent of all macrophage populations examined, is accessible to galactose oxidase/NaB3H4 labeling on the surface of TG-elicited and BCG-activated macrophages but not on resident macrophages; (b) GM1 is the predominant ganglioside constituent of the ...