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Full-Text Articles in Cancer Biology

Glycolipids Of The Mouse Peritoneal Macrophage. Alterations In Amount And Surface Exposure Of Specific Glycolipid Species Occur In Response To Inflammation And Tumoricidal Activation, Arthur M. Mercurio, Gerald A. Schwarting, Phillips W. Robbins Oct 1984

Glycolipids Of The Mouse Peritoneal Macrophage. Alterations In Amount And Surface Exposure Of Specific Glycolipid Species Occur In Response To Inflammation And Tumoricidal Activation, Arthur M. Mercurio, Gerald A. Schwarting, Phillips W. Robbins

Cancer Biology Publications and Presentations

We have characterized the major glycolipid constituents of the mouse peritoneal macrophage, and have demonstrated that alterations in the amount and in the accessibility of specific glycolipid species to galactose oxidase/NaB3H4 labeling, an indicator of glycolipid surface exposure, occur in response to inflammation and as a consequence of activation to a tumoricidal state. The key findings are: (a) Asialo GM1, a major neutral glycolipid constituent of all macrophage populations examined, is accessible to galactose oxidase/NaB3H4 labeling on the surface of TG-elicited and BCG-activated macrophages but not on resident macrophages; (b) GM1 is the predominant ganglioside constituent of the ...


The Cytotoxic And Kinetic Effects Of Asynchronous Cells Following The Administration Of Vincristine, Meri Firpo Apr 1984

The Cytotoxic And Kinetic Effects Of Asynchronous Cells Following The Administration Of Vincristine, Meri Firpo

Life and Environmental Sciences Undergraduate Theses

A growth curve was constructed for SCCVII-SF, a mouse squamous cell carcinoma cell line, in a culture of modified q-crle's medium. A toxicity curve was constructed for vincristine ,nd SCCVII-SF cells in the exponential phase of growth. Cells in mid-exponential phase were treated with a subtoxic level of vincristine for four hours. A count of mitotic cells was taken at intervals to determine whether vincristine caused a buildup of cells in mitosis after its removal. Results showed that cells continued to collect in mitosis for four hours after the removal of vincristine.


The Late Effects Of Terminated Protracted Whole-Body 60 Co Gamma Irradiation On Beagle Dogs, Mark Elliott Apr 1984

The Late Effects Of Terminated Protracted Whole-Body 60 Co Gamma Irradiation On Beagle Dogs, Mark Elliott

Life and Environmental Sciences Undergraduate Theses

Beagle dogs exposed to protracted Co gamma irradiation were observed for late effects, particularly life shortening ® and fatal tumor incidence. A total of 86 controls and 136 irradiated beagles entered the study, with 60% of these dead as of October 1, 1983. A nearly equal number of beagles of both sexes began If-ray exposure at 400 days of age. The 6 0 Co ¥-rays were given to predetermined total exposures of 600, 1400, 2000, and 4000 R at rates of 5, 10, 17, and 35 R/ day (22 hours/day, 7 days/week), with a few exceptions. Although 40% of ...