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Cancer Biology Commons

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Full-Text Articles in Cancer Biology

Effects Of Combination Drug Therapy On The Subcutaneous And Pulmonary Growth Of A Slow And A Fast-Growing C3h/He Mammary Carcinoma, J. Vaage, Mary E. Costanza Nov 1979

Effects Of Combination Drug Therapy On The Subcutaneous And Pulmonary Growth Of A Slow And A Fast-Growing C3h/He Mammary Carcinoma, J. Vaage, Mary E. Costanza

Women’s Health Research Faculty Publications

Changes in susceptibility to treatment with Cytoxan, methotrexate, 5-fluorouracil, and Adriamycin, single or in combination, have been studied during the initial and progressive stages of s.c. and pulmonary (via tail vein injection) growth of two transplanted syngeneic C3H/He mammary carcinomas. One tumor was fast growing, reaching a size of 3 mm from a 1-mm s.c. implant in 7 days; the second tumor would grow to the same size in 30 days. The tumor with the slower growth rate was more susceptible to drug treatment, manifested by delayed growth as well as by prevented growth. The slower-growing tumor ...


Detection Of Unique Tumor-Associated Proteins In The Urine Of Patients With Transitional Cell Carcinoma By High Resolution Two-Dimensional Polyacrylamide Gel Electrophoresis, Robert David Lehman Jul 1979

Detection Of Unique Tumor-Associated Proteins In The Urine Of Patients With Transitional Cell Carcinoma By High Resolution Two-Dimensional Polyacrylamide Gel Electrophoresis, Robert David Lehman

Biological Sciences Theses & Dissertations

A two-dimensional polyacrylamide gel electrophoretic technique was developed for the detection of unique tumor-associated proteins in urine of patients with transitional cell carcinoma (TCC) of the urinary bladder. This technique yielded high resolution of polypeptides in the urine of cancer patients. Urine was chosen as a source of tumor-associated components because the location of the tum or should release already solublized tum or substances in to the urine.

Urinary proteins were concentrated and then analyzed by the two - dimensional electrophoretic technique using isoelectric focusing in the first dimension and sodium dodecylsulfate - polyacrylamide gel electrophoresis in the second dimension. Ten transitional ...


Effects Of High Dose Ascorbate On Tumor Growth In Guinea Pigs, Brian O'Hollaren Apr 1979

Effects Of High Dose Ascorbate On Tumor Growth In Guinea Pigs, Brian O'Hollaren

Life and Environmental Sciences Undergraduate Theses

Recent studies indicate that a host's susceptibility to cancer is determined to a large extent by the natural resistance of the host to the disease (1). Consequently, there has developed a wave of interest concerning the theory that measures designed to enhance host resistance will result in an inhibition of malignant invasive growth. One important factor in host resistance is the availability of ascorbic acid (2-4). It has been shown that ascorbate can be used to inhibit in-vivo formation of highly carcinogenic N-nitroso compounds (5, 11). In tumorigenesis experiments, ascorbate inhibited lung adenoma induction in A strain mice by ...