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Articles 1 - 17 of 17

Full-Text Articles in Cancer Biology

Head And Neck Cancers, James Liebmann, Ali Akalin, Liana Puscas, Andrew Chen, Richard S. Pieters Mar 2019

Head And Neck Cancers, James Liebmann, Ali Akalin, Liana Puscas, Andrew Chen, Richard S. Pieters

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of head and neck cancers, including epidemiology, etiology, screening, pathology, staging, and treatment. The chapter focuses on cancers of the upper aerodigestive tract which are most often squamous cell carcinomas arising from the squamous epithelium that lines the tract.


Using Non Stem-Cells To Understand Early Tumor Growth, Jake Hogan, Heiko Enderling, Joel Brown, Robert A. Gatenby Sep 2018

Using Non Stem-Cells To Understand Early Tumor Growth, Jake Hogan, Heiko Enderling, Joel Brown, Robert A. Gatenby

Library/Life Sciences Undergraduate Poster Competition 2018

Tumors of similar size and shape can exhibit different responses to the same treatment. Targeted therapy aims to better treat these tumors by classifying them according to genotypic traits. A better understanding of how tumor traits such as non-stem cells influence tumor growth could improve targeted therapy. We hypothesize that the production of non-stem cells may aid tumor growth in avascular tumors (tumors lacking blood vessels).


The Pathology Of Cancer, Chi Young Ok, Bruce A. Woda, Elizabeth Kurian Aug 2018

The Pathology Of Cancer, Chi Young Ok, Bruce A. Woda, Elizabeth Kurian

Cancer Concepts: A Guidebook for the Non-Oncologist

Patients and physicians depend on pathologists to make the diagnosis of cancer and of the specific type of cancer. Pathologists are expert in pattern recognition and in the natural history of diseases, including cancers. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will describe the pathology of cancer.


Mlk Book Read 2018 (Research Materials), Holy Cross Libraries Jan 2018

Mlk Book Read 2018 (Research Materials), Holy Cross Libraries

Library Resources for Campus Events

A bibliography of resources available through the Holy Cross Libraries which provide additional information related to the MLK Winter Book Read, based on the best-seller “The Immortal LIfe of Henrietta Lacks” by Rebecca Skoot.


Cancer Biology, Bruce A. Woda, James Liebmann, Elizabeth Kurian Mar 2016

Cancer Biology, Bruce A. Woda, James Liebmann, Elizabeth Kurian

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist focuses on DNA mutations that cause cancer, abnormal regulation of cell growth and death, and metastasis.

Updated March 2016 version posted March 28, 2017.


Cancer Treatment Drugs, Richard J. Horner Feb 2016

Cancer Treatment Drugs, Richard J. Horner

Cancer Concepts: A Guidebook for the Non-Oncologist

Over eighty different compounds have been approved to treat cancer. Their mechanisms of action, effectiveness against specific cancers, and potential toxicity vary greatly. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will describe, in terms of mechanism of action, the most important classes of cytotoxic and targeted therapies as well as their most characteristic side effects and clinical uses. A table summarizing the classes of drugs and representative members of those classes is included at the end of the chapter. Rather than an encyclopedia, this will be a schematic diagram or roadmap to more detailed knowledge that you ...


Familial Cancer Syndromes, Beverly N. Hay Feb 2016

Familial Cancer Syndromes, Beverly N. Hay

Cancer Concepts: A Guidebook for the Non-Oncologist

While the majority of cancers are not inherited, there are a number of well described collections of cancers that occur within families. These cancer syndromes were initially identified based on observation of the family history and subsequently the molecular mechanisms have been elucidated. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist is intended to allow the reader to recognize when a pattern of cancers occurs in an individual or their family, and to generate an investigation into potential cancer syndromes. With the rapidly expanding understanding of the molecular basis of cancers at the cellular and constitutional levels, appropriate ...


Lung Cancer And Mesothelioma, Jeffrey A. Gordon, Elizabeth Kurian, Arash Bedayat, Ali Akalin, Karl Uy, Richard S. Pieters Dec 2015

Lung Cancer And Mesothelioma, Jeffrey A. Gordon, Elizabeth Kurian, Arash Bedayat, Ali Akalin, Karl Uy, Richard S. Pieters

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of lung cancer and mesothelioma, including epidemiology, etiology, screening, pathology, staging, and treatment.


Environmental And Infectious Causes Of Malignancy, Mary Linton Peters, Richard S. Pieters, James Liebmann Nov 2015

Environmental And Infectious Causes Of Malignancy, Mary Linton Peters, Richard S. Pieters, James Liebmann

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents a summary of the most relevant causative agents of cancer. Exposure to many environmental agents is associated with an increased incidence of certain malignancies, although causation is usually difficult to prove. Certain chemicals, infections (parasitic, viral, and bacterial) and ionizing radiation are known carcinogens. Variable genetic susceptibility to carcinogenesis is apparent. Up to 2/3 of human cancers are believed to have an environmental component.


Epidemiology And The Cancer Problem, Shakeeb Yunus Oct 2015

Epidemiology And The Cancer Problem, Shakeeb Yunus

Cancer Concepts: A Guidebook for the Non-Oncologist

Epidemiology is the study of populations using defined research methods to confirm the patterns and causes of disease and applying this information to improve the health of the populations. This branch of science is the basis for understanding the spread of diseases in a defined area or group of people. Epidemiologic studies have been instrumental in improving outcomes by establishing preventive and therapeutic measures for the incidence, prevalence and mortality from cancers. The incidence of malignancy in a country or in our world defines the magnitude of the cancer problem. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist ...


Pediatric Oncology Principles, Christopher P. Keuker Sep 2015

Pediatric Oncology Principles, Christopher P. Keuker

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of childhood cancer, including the incidence, distribution, diagnosis, treatment, and survivorship.


Breast Cancer, Maria Giulia Cicchetti, James Liebmann, Andrew Chen, Carolynn Debenedectis, Elizabeth Kurian Aug 2015

Breast Cancer, Maria Giulia Cicchetti, James Liebmann, Andrew Chen, Carolynn Debenedectis, Elizabeth Kurian

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an overview of breast cancer, including etiology, screening, pathology, staging, and treatment.


Cancers Of Unknown Primary, Amanpreet Buttar, Laura A. Lambert, James Liebmann, Richard S. Pieters Aug 2015

Cancers Of Unknown Primary, Amanpreet Buttar, Laura A. Lambert, James Liebmann, Richard S. Pieters

Cancer Concepts: A Guidebook for the Non-Oncologist

Cancers of unknown primary (CUP) are a heterogeneous group of histologically proven metastatic tumors whose primary site can't be determined after a standard diagnostic and pathologic work-up. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents provides an overview of cancers of unknown primary, including initial evaluation and principles of treatment.


Introduction To Cancer Concepts: A Guidebook For The Non-Oncologist, Richard S. Pieters, Maryann Bishop-Jodoin, James Liebmann Sep 2014

Introduction To Cancer Concepts: A Guidebook For The Non-Oncologist, Richard S. Pieters, Maryann Bishop-Jodoin, James Liebmann

Cancer Concepts: A Guidebook for the Non-Oncologist

This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist presents an introduction to the Guidebook, which developed from the Cancer Concepts course at the University of Massachusetts Medical School.


Exploring New Chemotherapeutic Strategies Against Brain Cancer, Seol Kim, Anthony J. Berdis Sep 2013

Exploring New Chemotherapeutic Strategies Against Brain Cancer, Seol Kim, Anthony J. Berdis

Undergraduate Research Posters 2013

Approximately 4,000 children in the United States are diagnosed each year with a brain tumor. Brain cancers are the deadliest of all pediatric cancers as they have survival rates of less than 20%. Typical treatments include surgery and radiation therapy. However, chemotherapy is the primary therapeutic option for children, especially against aggressive brain tumors. An important chemotherapeutic agent is temozolomide, an alkylating agent that causes cell death by damaging DNA. In this project, we tested the ability of non-natural nucleosides developed in our lab in order to increase the ability of temozolomide to kill brain cancer cells. Our results ...


Staging Of Cancer, Mary Linton Peters, Richard S. Pieters, James Liebmann, Geoffrey Graeber May 2013

Staging Of Cancer, Mary Linton Peters, Richard S. Pieters, James Liebmann, Geoffrey Graeber

Cancer Concepts: A Guidebook for the Non-Oncologist

The “stage” of a cancer is a short-hand way of describing the extent of cancer in a patient. Stage is based on macroscopic involvement of tissues by cancer. Staging of cancer occurs prior to the beginning of treatment, or at the first definitive surgery. Clinical staging, which includes radiography and exam findings, takes place initially. Pathologic staging, which is obtained from surgical specimens, can be acquired during the course of surgical treatment. Patients then carry either the clinical stage or the pathologic stage for the duration of their illness. This chapter in Cancer Concepts: A Guidebook for the Non-Oncologist will ...


Policy For Identifying And Assessing The Health Risks Of Toxic Substances, Maine Bureau Of Health Feb 1988

Policy For Identifying And Assessing The Health Risks Of Toxic Substances, Maine Bureau Of Health

Maine Collection

Policy for Identifying and Assessing the Health Risks of Toxic Substances

by Norman T. Anderson, Environmental Toxicology Program, Division of Disease Control, Bureau of Health (February, 1988).

Contents: Section I: Introduction / Section II: Methods / Section III: Exposure Assessment / Section IV: Hazard Identification / Section V: Hazard Assessment / Section VI: Risk Characterization / List of Figures / List of Tables