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Cancer Biology Commons

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Articles 1 - 9 of 9

Full-Text Articles in Cancer Biology

Mien1 Drives Breast Cancer Invasion By Regulating Cytoskeletal-Focal Adhesions Dynamics, Marilyne F. Kpetemey B.S. May 2015

Mien1 Drives Breast Cancer Invasion By Regulating Cytoskeletal-Focal Adhesions Dynamics, Marilyne F. Kpetemey B.S.

Theses and Dissertations

In the recent years, Migration and Invasion Enhancer 1(MIEN1) has emerged as a potential biomarker and a plausible target in breast cancer. Located in the 17q12-21 region of the human chromosome, next to the Her-2/neu loci, MIEN1 presents a robust expression in breast carcinomas; however is completely absent or low in the normal tissues. MIEN1 is post-translationally modified by geranyl-geranyl transferase-I (GgtaseI), which adds isoprenyl group to the carboxyl-terminal of the protein. Prenylated MIEN1 then associates with the inner leaflet of the plasma membrane and acts as an adaptor protein triggering downstream signaling through the Akt/NF-kB axis ...


Extracellular Proliferating Cell Nuclear Antigen As A Marker And Therapeutic Target For Cancer Stem Cells., Nathan C. Horton May 2014

Extracellular Proliferating Cell Nuclear Antigen As A Marker And Therapeutic Target For Cancer Stem Cells., Nathan C. Horton

Theses and Dissertations

Cancer is the second leading cause of death in the United States, making it a major public health issue. Due to increased efficiency in detecting and treating cancer, primary tumors account for only 10% of cancer mortalities. Today, the majority of cancer related deaths are due to metastasis and relapse after therapy, which current cancer treatments fail to prevent. Recently, cancer stem cells (CSCs) have emerged as being responsible for metastasis and relapse. CSCs are cancerous cells with stem cell characteristics including self renewal and the ability to evade chemotherapy and elimination by the immune system. A part of the ...


Optimization Of Reconstituted High Density Lipoprotein Nanoparticles As A Delivery System For Neuroblastoma, Cheryl L. Hinze Dec 2013

Optimization Of Reconstituted High Density Lipoprotein Nanoparticles As A Delivery System For Neuroblastoma, Cheryl L. Hinze

Theses and Dissertations

Despite many advances in cancer therapy over the last few decades, cancer remains one of the most common causes of death in not only the United States, but around the world. Two of the major problems cancer patients face today are the horrific side effects associated with chemotherapy, and the development of drug resistance. Both of these become even bigger problems when they are applied to children. Neuroblastoma is one of the most common forms of pediatric cancer. High risk Neuroblastoma patients are commonly faced with intensive multi-modal therapies in attempt to overcome a very aggressive disease. Due to the ...


Protein Kinase C-Eta Signalling In Breast Cancer, Deepanwita Pal Dec 2013

Protein Kinase C-Eta Signalling In Breast Cancer, Deepanwita Pal

Theses and Dissertations

Pal, Deepanwita, Protein kinase C-eta signaling in breast cancer. Doctor of Philosophy (Biochemistry and Molecular Biology), November, 2013, 117 pp, 14 illustrations, 260 References Protein kinase C-eta (PKCη) is a novel member of the PKC family that is important for several cellular processes. PKCη is overexpressed in breast cancer and has been associated with chemotherapeutic resistance. PKCη is the only phorbol ester-sensitive PKC isozyme that resists downregulation upon prolonged treatment with tumorpromoting phorbol esters suggesting its unique regulation. The purpose of this dissertation is to elucidate the mechanism of PKCη regulation and its functional relevance in breast cancer. We have ...


Astrocyte Elevated Gene-1, A Novel Modulator Of Astrocyte Function: Implications For Neuroaids, Aging And Glioblastoma, Neha Vartak Dec 2013

Astrocyte Elevated Gene-1, A Novel Modulator Of Astrocyte Function: Implications For Neuroaids, Aging And Glioblastoma, Neha Vartak

Theses and Dissertations

Vartak-Sharma, Neha N., Astrocyte elevated gene-1, a novel modulator of astrocyte function: Implications for NeuroAIDS, aging and glioblastoma. Doctor of Philosophy (Biomedical Sciences), Nov, 2013, 180 pp., 1 table, 40 illustrations, 336 bibliographies. Recent attempts to analyze human immunodeficiency virus (HIV)-1-induced gene expression changes in astrocyte identified a multifunctional oncogene, astrocyte elevated gene-1 (AEG-1), as an HIV-1 and tumor necrosis factor-inducible transcript. Subsequently, due to its homology to mouse breast cancer metastasis protein, metadherin, AEG-1 was largely implicated in carcinogenesis of diverse cancer types. However, the role of AEG-1 in astrocytes, the original cell type in which AEG-1 ...


Involvement Of S6 Kinase In Breast Cancer, Savitha Sridharan Dec 2013

Involvement Of S6 Kinase In Breast Cancer, Savitha Sridharan

Theses and Dissertations

Sridharan, S., Involvement of S6 Kinase in Breast Cancer. Doctor of Philosophy (Cancer Biology), November 2013, 129pp, 19 illustrations, 215 references. The 40S ribosomal protein S6 Kinase (S6K) is activated downstream of the mammalian target of rapamycin (mTOR)and is believed to play and important role in protein translation. In mammalian cells S6K is represented by two highly homologous proteins, S6K1 and S6K2. Both homologs have been shown to be amplicfied and over expressed in breast cancer cells and tissues. While the regulation and functions of S6K1 have been addressed, little is known about those of S6K2 . Hence we sought ...


Role Of Nk Cell Receptors In Acute Lymphoblastic Leukemia In Children, Charisse Tan Dec 2013

Role Of Nk Cell Receptors In Acute Lymphoblastic Leukemia In Children, Charisse Tan

Theses and Dissertations

Tan, Charisse S., Role of NK Cell Receptors in Acute Lymphoblastic Leukemia in Children. Master of Science (Biomedical Sciences), May, 2013, 94 pp., 6 tables, 57 illustrations, bibliography, 35 titles. Due to the many medical advances in recent years, treatment of acute lymphoblastic leukemia (ALL) has improved tremendously. It has been estimated that about 80% of children that are diagnosed with this disease will likely go into remission. However, there is still a need for a more specific, less invasive treatment that lessens any toxic side effects of current cancer treatments and at the same time, lowers the risk of ...


Involvement Of Estrogen Receptor Beta 5 In The Progression Of Glioma, Wenjun Li May 2013

Involvement Of Estrogen Receptor Beta 5 In The Progression Of Glioma, Wenjun Li

Theses and Dissertations

Emerging evidence suggests a decline of ERβ expression in various peripheral cancers and ERβ has been proposed as a cancer brake that inhibits tumor cell growth and proliferation. In the current study, we have identified ERβ5 as the predominant isoform of ERβ in human glioma and its expression was significantly increased in human glioma as compared with non-neoplastic brain tissue. Hypoxia and activation of hypoxia inducible factor (HIF) increased ERβ transcription in U87 cells, suggesting elevated ERβ expression in glioma might be induced by the hypoxic stress in the tumor. Overexpression of either ERβ1 or ERβ5 increased PTEN expression and ...


Lymphatic Pump Treatment Enhances Pulmonary Immunity And Inhibits Solid Tumor Formation In The Lung, Mayela Pedrueza Dec 2009

Lymphatic Pump Treatment Enhances Pulmonary Immunity And Inhibits Solid Tumor Formation In The Lung, Mayela Pedrueza

Theses and Dissertations

No abstract provided.