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Cancer Biology Commons

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University of Arkansas, Fayetteville

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Medicine and Health Sciences

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Full-Text Articles in Cancer Biology

Rna Sequencing In The Development Of Cancer-Cachexia, Thomas Allen Blackwell Aug 2017

Rna Sequencing In The Development Of Cancer-Cachexia, Thomas Allen Blackwell

Theses and Dissertations

Introduction: Cancer is a major public health problem in the U.S. and the world. In 2013 there were an estimated 1,660,290 new cases of cancer in the U.S. Cancer-Cachexia (CC) is a common effect of many cancers, and is directly responsible for 20-40% of cancer-related deaths. The mechanisms that control the development of CC are not well understood. Most investigations of CC focus on the post-cachectic state and do not examine the progression of the condition. The purpose of this study was to utilize RNA sequencing to analyze transcriptomic alterations throughout the progression of CC. Methods ...