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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Genetic Variation And Evolution Of Equine Infectious Anemia Virus Rev Quasispecies During Long Term Persistent Infection , Prasith Baccam Jan 2000

Genetic Variation And Evolution Of Equine Infectious Anemia Virus Rev Quasispecies During Long Term Persistent Infection , Prasith Baccam

Retrospective Theses and Dissertations

Genetic variation has been observed in many viruses. Viruses that carry their genetic information in the form of RNA exhibit high mutation rates because the viral polymerase lacks proof-reading mechanisms commonly found in DNA polymerase complexes. The combination of high mutation rates, small genome size, and high replication rates results in a population of closely related viral genotypes, which are commonly referred to as a quasispecies. A consequence of the genetic variation in viruses is possible variation in viral phenotype of the quasispecies population. Furthermore, changes in viral phenotype may be a biologically important factor in progression of disease. Here ...