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Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

2016

Dunk

Articles 1 - 1 of 1

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Flow-Dependent Myosin Recruitment During Drosophila Cellularization Requires Zygotic Dunk Activity, Bing He, Adam Martin, Eric Wieschaus May 2016

Flow-Dependent Myosin Recruitment During Drosophila Cellularization Requires Zygotic Dunk Activity, Bing He, Adam Martin, Eric Wieschaus

Open Dartmouth: Peer-reviewed articles by Dartmouth faculty

Actomyosin contractility underlies force generation in morphogenesis ranging from cytokinesis to epithelial extension or invagination. In Drosophila, the cleavage of the syncytial blastoderm is initiated by an actomyosin network at the base of membrane furrows that invaginate from the surface of the embryo. It remains unclear how this network forms and how it affects tissue mechanics. Here, we show that during Drosophila cleavage, myosin recruitment to the cleavage furrows proceeds in temporally distinct phases of tension-driven cortical flow and direct recruitment, regulated by different zygotic genes. We identify the gene dunk, which we show is transiently transcribed when cellularization starts ...