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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

You Are What You Eat At Any Age: Carbon And Nitrogen Analysis Of Mummies From An Ancient Egyptian Necropolis, Stephen Funk, R. Paul Evans Apr 2019

You Are What You Eat At Any Age: Carbon And Nitrogen Analysis Of Mummies From An Ancient Egyptian Necropolis, Stephen Funk, R. Paul Evans

Library/Life Sciences Undergraduate Poster Competition 2019

The BYU Egypt Project at Fag el-Gamus necropolis and adjacent Seila Pyramid has studied over 700 mummies excavated over the past 30 years. The necropolis includes an open area with densely located vertical burial shafts and a hill with horizontal burial shafts. The chronological and dietary history of the mummies was assessed using stable isotopy and 14C analysis of accessible biological samples.


Living, Learning, And Leading At Linfield College, Kelsey Bruce Mar 2019

Living, Learning, And Leading At Linfield College, Kelsey Bruce

Student Engagement Posters

Kelsey Bruce discusses student engagement at Linfield College with regard to leadership through student/faculty collaborative research with Dr. Megan Bestwick, speech and debate, and the Linfield Residence Life team.


Chemical Analysis Of Aerosol Particle Surfaces, Hillary Woolf Dec 2018

Chemical Analysis Of Aerosol Particle Surfaces, Hillary Woolf

Fall Student Research Symposium 2018

Aerosol particles are thought to impact climate properties. The ability to probe aerosols to understand their chemical properties has been difficult due to a lack of appropriate analytical techniques. Here we present interface-specific SHS techniques to allow for in situ analysis of aerosol particles. Transportation of aerosols from their collection site to the laboratory disturbs their chemical and physical properties thus making it difficult to take accurate measurements of aerosol particles. We show that using a CCD detector is a more effective option for producing more sensitive results and can greatly reduce sampling time and could possibly detect measurements from ...


Carbohydrate Extraction From The Chorella Vulgaris Microalgae Strain, William Hammann, Wayne Seames, Andrew Ross Dec 2018

Carbohydrate Extraction From The Chorella Vulgaris Microalgae Strain, William Hammann, Wayne Seames, Andrew Ross

Essential Studies UNDergraduate Showcase

The cultivation and exploitation of microalgae biomass as a source of renewable fuels and other chemicals has been an active area of research due to microalgae’s high productivity and the relatively high concentrations of valuable intracellular components, like lipids (fatty acid-based oils), proteins, and polysaccharides. Commercialization of this technology will help mitigate global climate change by reducing fossil-derived products by producing analog renewable fuels and chemicals. Traditionally, the main focus of microalgae-based fuels/chemicals research and development has been on the lipids that many strains generate, but current research shows that solely recovering the oils may not be cost ...


Basic Cell And Molecular Biology 3e: What We Know And How We Found Out, Gerald Bergtrom Sep 2018

Basic Cell And Molecular Biology 3e: What We Know And How We Found Out, Gerald Bergtrom

Cell and Molecular Biology 3e: What We Know and How We Found Out - All Versions

No abstract provided.


Annotated Cell And Molecular Biology 3e: What We Know And How We Found Out, Gerald Bergtrom Jul 2018

Annotated Cell And Molecular Biology 3e: What We Know And How We Found Out, Gerald Bergtrom

Cell and Molecular Biology 3e: What We Know and How We Found Out - All Versions

No abstract provided.


Progress Toward Synthetically Simplified Natural Anticancer Peptide, David W. Kastner, Steven L. Castle Mar 2018

Progress Toward Synthetically Simplified Natural Anticancer Peptide, David W. Kastner, Steven L. Castle

Library/Life Sciences Undergraduate Poster Competition 2018

Yaku’amide A was isolated in late 2010 from the deep-sea sponge Ceratopsion sp. and exhibits potent inhibitory activity against 39 human cancer cell lines via a potentially novel mode of action. However, the total synthesis requires many steps and produces low yields. In this study, we determined two simpler YA analogues that may retain its anticancer properties and can be synthesized in larger quantities. The analogues replace dehydroisoleucine with either dehydroethylnorvaline or dehydrovaline.


Audiobook Of A World From Dust, Ben Mcfarland Jan 2018

Audiobook Of A World From Dust, Ben Mcfarland

Faculty Open Access Books

A World From Dust is a popular science book about the chemical sequence behind the evolution of creation.

It’s about how geology, biology, and chemistry worked together over billions of years, providing a hidden order under the random flow of genes and lava and water.

It’s about the chemical job that each element takes up in life, and how that job is predictable from its place on the periodic table.

It can be told as the story of many elements: how iron and sulfur gave a spark of life; how manganese was a key for oxygen; and how ...


Biochemistry, Chavonda Mills, Shaundra Walker Jul 2017

Biochemistry, Chavonda Mills, Shaundra Walker

Chemistry Grants Collections

This Grants Collection for Biochemistry was created under a Round Five ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

  • Linked Syllabus
  • Initial Proposal
  • Final Report


Life Line June 2017, Sarah Bouchard Jun 2017

Life Line June 2017, Sarah Bouchard

Life Line - The Biology Department Newsletter

Research presented at Intl. Coral Reef Symposium - Mussels - South African Internship Experience - EHS Degree Coming - Otterbein Rock Garden - Nicaragua - Chris Shockley


Characterization Of A Putative Hemolysin Expressed By Sneathia Amnii, A Preterm Birth-Associated Pathogen, Lizette Carrasco, Kimberly Jefferson Jan 2017

Characterization Of A Putative Hemolysin Expressed By Sneathia Amnii, A Preterm Birth-Associated Pathogen, Lizette Carrasco, Kimberly Jefferson

Undergraduate Research Posters

The gram-negative bacteria Sneathia amnii is a poorly-characterized commensal of the female urogenital tract frequently associated with adverse clinical outcomes such as bacterial vaginosis (BV), amnionitis, and preterm labor. To investigate its potential role in virulence, we sought to identify and characterize virulence determinants produced by S. amnii in an effort to better understand the pathogenesis of infectious preterm birth. Through sequencing of the Sn35 genome (type strain of S. amnii), we identified two genes with amino acid sequence similarity and structural similarity to the filamentous hemagglutinin (FHA) protein of Bordetella pertussis and its Type Vb transporter. Because S. amnii ...


Evolution Of Protein Complexes In Bacterial Species, Shwetha Hara Sridhar, Wedad Albalawi, Peter Uetz Jan 2017

Evolution Of Protein Complexes In Bacterial Species, Shwetha Hara Sridhar, Wedad Albalawi, Peter Uetz

Undergraduate Research Posters

Protein complexes are composed of two or more associated polypeptide chains that may have different functions. Protein complexes play a critical role for all processes in life and are considered as highly conserved in evolution. In previous studies, protein complexes from E. coli or Mycoplasma pneumoniae have been characterized experimentally, revealing that a typical bacterial cell has on the order of 500 protein complexes. Using gene homology (orthology), these experimentally-observed complexes can be used to predict protein complexes across many species of bacteria. Surprisingly, the majority of protein complexes is not conserved, demonstrating an unexpected evolutionary flexibility.

The current research ...


The Extension Of Rbc Longevity And Functionality In The Prevention Of Graft Versus Host Disease, Shanmuka Gadiraju, Megh Kumar Jan 2017

The Extension Of Rbc Longevity And Functionality In The Prevention Of Graft Versus Host Disease, Shanmuka Gadiraju, Megh Kumar

Undergraduate Research Posters

Given today’s current scientific method of preservation, red blood cells (RBCs) donated or drawn from live humans have a storage life of approximately 42 days, after which the blood will be discarded due to of degradation of the RBCs. The mechanism that drives said degradation is known as oxidative stress, in which the cells’ inability to balance out the creation and excretion of free radicals causes a conformational change in the shape and efficacy of RBCs. In order to counteract the oxidative actions upon the cells, it has been thought that the addition of reducing agents, specifically ascorbic acid ...


Separation Of Blood Mixtures Using Fluorescently Labeled Antibodies, Christopher Ehrhardt, Dani Jabado, Emily Brocato Jan 2017

Separation Of Blood Mixtures Using Fluorescently Labeled Antibodies, Christopher Ehrhardt, Dani Jabado, Emily Brocato

Undergraduate Research Posters

Identifying and analyzing biological mixture samples at a crime scene are of paramount concern for forensic scientists, especially if that type of evidence contains only one cell type. The presence of multiple contributors in a biological evidence sample reduces the probative value of DNA evidence and can sometimes lead to its eventual loss of value. As such, this study was performed in an attempt to examine and evaluate flow cytometry analysis as a means to separate blood mixture samples labeled with fluorescent antibodies. Fluorescein Isothiocyanate (FITC) antibodies were specifically targeted and bound to HLA (Human Leukocyte Antigens) markers present on ...


Separation Of Blood Mixtures Using Fluorescently Labeled Antibodies, Dani Jabado Jan 2017

Separation Of Blood Mixtures Using Fluorescently Labeled Antibodies, Dani Jabado

Undergraduate Research Posters

Identifying and analyzing biological mixture samples at a crime scene are of paramount concern for forensic scientists, especially if that type of evidence contains only one cell type. The presence of multiple contributors in a biological evidence sample reduces the probative value of DNA evidence and can sometimes lead to its eventual loss of value. As such, this study was performed in an attempt to examine and evaluate flow cytometry analysis as a means to separate blood mixture samples labeled with fluorescent antibodies. Fluorescein Isothiocyanate (FITC) antibodies were specifically targeted and bound to HLA (Human Leukocyte Antigens) markers present on ...


Frozen Brain Atlas, Natalie Andrea Builes, Dominick Joseph Casciato, Samantha Taylor Bergoine, Robert Speth Sep 2016

Frozen Brain Atlas, Natalie Andrea Builes, Dominick Joseph Casciato, Samantha Taylor Bergoine, Robert Speth

Frozen Brain Atlas

The Frozen Brain Atlas provides students, educators, and scientists with a tool to further explore the architecture of the brain. Current brain atlases allow users to navigate sectioned brain tissue using histological staining; however, they fail to capture naturally visible structures post sectioning. Through immediate post sectioning image collection, the natural contrast of the brain reveals unique structural details that are rarely seen by traditional staining procedures. By utilizing indexing and interactive labeling, the Nova Southeastern University Frozen Brain Atlas will allow identification of brain regions when used as a correlative tool for modalities including receptor autoradiography, immunofluorescence, and other ...


Science, Physiology, And Nutrition For The Nonscientist, Judi S. Morrill Sep 2016

Science, Physiology, And Nutrition For The Nonscientist, Judi S. Morrill

Open Educational Resources

A wonderful blend of physiology, nutrition, biochemistry, genetics, biology, evolution, chemistry--what we all need to know as informed citizens. A basic knowledge of the life sciences and how our bodies work--to promote our own good health, especially as we're bombarded with misleading advertisements, soundbites, and the like. DNA fingerprinting, calorie requirements, dietary advice, genetic engineering (including gene editing with CRISPR cas9)--all in an easy-to understand book.


Reduction Of Oxidative Stress And Storage Lesions (Rcsl) In Red Blood Cells - Analysis Of Ascorbic Acid (Aa), N-Acetylcysteine Amide (Ad4), And Serotonin (5-Ht), Shanmuka Gadiraju Jan 2016

Reduction Of Oxidative Stress And Storage Lesions (Rcsl) In Red Blood Cells - Analysis Of Ascorbic Acid (Aa), N-Acetylcysteine Amide (Ad4), And Serotonin (5-Ht), Shanmuka Gadiraju

Undergraduate Research Posters

Oxidative stress is a common occurrence in red blood cell (RBC) storage in blood banks throughout the world. Typically RBC units stored under routine standard protocol (stored in SAGM-CPD additive solution) can only be kept up to 42 days for transfusion usage before being discarded. I am studying the effects of Ascorbic Acid (AA), N-acetylcysteine amide (AD4), and Serotonin (5-HT) as additives in blood bank storage because I want to find out if these additives can reduce storage-induced oxidative stress on red blood cells (RBCs), in order to help my reader understand how potential blood storage additives can affect the ...


Scale Up Isolation Of Aaptamine For In Vivo Evaluation Indicates Its Neurobiological Activity Is Linked To The Delta Opioid Receptor, Eptisam M. Lambo, Nicole L. Mcintosh, Madeline Ferwerda, Allison Coker, Laura Milan-Lobo, Nicholas Lorig-Roache, Phillip Crews, Jennifer L. Whistler May 2015

Scale Up Isolation Of Aaptamine For In Vivo Evaluation Indicates Its Neurobiological Activity Is Linked To The Delta Opioid Receptor, Eptisam M. Lambo, Nicole L. Mcintosh, Madeline Ferwerda, Allison Coker, Laura Milan-Lobo, Nicholas Lorig-Roache, Phillip Crews, Jennifer L. Whistler

Student Research Posters

Opioid receptors belong to the large superfamily of seven transmembrane-spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of fundamental physiological importance mediating the actions of the majority of known neurotransmitters and hormones. The Mu (µ), Delta (δ) and Kappa (MOR, DOR, KOR) opioid receptors are particularly intriguing members of this receptor family as they are the targets involved in many neurobiological diseases such as addiction, pain, stress, anxiety, and depression. To date few marine natural products have been investigated for their neurobiological activities.1 One noteworthy example involves ziconotide (1) from the cone snail Conus magnus.2 ...


Modeling Atp-Binding Cassette G2 (Abcg2) Substrate Specificity, Raghav D. Acharya, Aurijit Sarkar, Glen E. Kellogg Jan 2015

Modeling Atp-Binding Cassette G2 (Abcg2) Substrate Specificity, Raghav D. Acharya, Aurijit Sarkar, Glen E. Kellogg

Undergraduate Research Posters

How well can we predict efflux by ATP-binding cassette G2?

It is estimated that there will be about 1.6 million new cases of cancer and half a million cancer deaths in the US during 2015.ATP-binding cassette (ABC) efflux transporters such as ABCG2 are overexpressed in chemotherapy-resistant cancer cells. Anticancer drugs are prone to efflux by these transporters. Being able to identify drugs that are effluxed is of great interest in drug discovery.The current arsenal of methods used to detect efflux are not easily adaptable to high throughput formats and are limited in scope, making experimental analysis an ...


Scale Up Isolation Of Aaptamine For In Vivo Evaluation Indicates Its Neurobiological Activity Is Linked To The Delta Opioid Receptor, Nicole L. Mcintosh, Eptisam Lambo, Laura Millan-Lobo, Fei Li, Li He, Phillip Crews, Jennifer L. Whistler, Tyler Johnson Jan 2015

Scale Up Isolation Of Aaptamine For In Vivo Evaluation Indicates Its Neurobiological Activity Is Linked To The Delta Opioid Receptor, Nicole L. Mcintosh, Eptisam Lambo, Laura Millan-Lobo, Fei Li, Li He, Phillip Crews, Jennifer L. Whistler, Tyler Johnson

Student Research Posters

Opioid receptors belong to the large superfamily of seven transmembrane-spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of fundamental physiological importance mediating the actions of the majority of known neurotransmitters and hormones. The Mu, Delta, and Kappa (MOP, DOP, KOP) opioid receptors are particularly intriguing members of this receptor family as they are the targets involved in many neurobiological diseases such as addiction, pain, stress, anxiety, and depression. Recently we discovered that the aaptamine class of marine sponge derived natural products exhibit selective agonist activity in vitro for the DOP versus MOP receptor. Our findings may explain ...


Activation Of Dna Damage Checkpoint Pathways During Skeletal Myoblast Differentiation And Apoptosis, Mofetoluwa Oluwasanmi, Greg Kliment, Crystal M. Weyman Sep 2014

Activation Of Dna Damage Checkpoint Pathways During Skeletal Myoblast Differentiation And Apoptosis, Mofetoluwa Oluwasanmi, Greg Kliment, Crystal M. Weyman

Undergraduate Research Posters 2014

A subset of skeletal myoblasts undergo apoptosis rather than differentiation when cultured in differentiation media (DM: absence of growth factors). While the muscle regulatory transcription factor MyoD is known to control the process of differentiation, our lab has recently discovered that MyoD is also controlling the apoptotic process in response to culture in DM by direct up-regulation of the pro-apoptotic Bcl2 family member PUMA. We similarly discovered that MyoD plays a role in the increased expression of PUMA and apoptosis in response to the DNA damaging agent, etoposide. This led to the hypothesis that culture in DM may lead to ...


Cholesterol Conjugated Hdac Inhibitor As Novel Anticancer Agent, Paul Orefice, Jane Peterson, Bin Sun Sep 2014

Cholesterol Conjugated Hdac Inhibitor As Novel Anticancer Agent, Paul Orefice, Jane Peterson, Bin Sun

Undergraduate Research Posters 2014

Histone deacetylase (HDAC) inhibitors are a class of promising new multifunctional anticancer agents. These agents are able to affect multiple epigenetic changes in aberrant cells. In addition to regulating the gene expression and transcription via chromatin remodeling, HDAC inhibitors can also modulate a variety of cellular functions including proliferation, differentiation, and apoptosis. Vorinostat (SuberAniloHydroxamic Acid, SAHA), the first HDAC inhibitor approved by FDA, inhibited the metastasis of various cancer cells. However, SAHA distributes in cancer tissue and normal tissue in a similar level. It will be ideal to selectively delivery SAHA into cancer cells. Rapidly growing cancer cells have a ...


Elcs In Ice: Cryo-Electron Microscopy Of Nuclear Envelope Limited Chromatin Sheets, Mikhail Eltsov, Sergey Sosnovksi, Ada L. Olins, Donald E. Olins Aug 2014

Elcs In Ice: Cryo-Electron Microscopy Of Nuclear Envelope Limited Chromatin Sheets, Mikhail Eltsov, Sergey Sosnovksi, Ada L. Olins, Donald E. Olins

Pharmaceutical Sciences Faculty Posters

Nuclear Envelope-Limited Chromatin Sheets (ELCS) form during excessive interphase nuclear envelope growth in a variety of cells. ELCS appear as extended sheets within the cytoplasm connecting distant nuclear lobes. Cross-section stained images of ELCS, viewed by transmission electron microscopy, resemble a sandwich of apposed nuclear envelopes separated by ~30 nm, containing a layer of ordered chromatin fibers. EM Procedures: The ultrastructure of ELCS was compared by three different methods: 1) aldehyde fixation/dehydration/plastic embedding/sectioning and staining; 2) high-pressure freezing/freeze substitution into plastic/sectioning and staining; 3) high-pressure freezing/cryo-sectioning/cryo-electron microscopy. Human leukemic (HL-60/S4) cells were ...


Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet Jan 2014

Integrating Phage Therapy Into Western Medicine, Jacob B. Jaminet

Undergraduate Research Posters

The World Health Organization has described the rise of antibiotic use as a “global heath security emergency” (who.int). With the growing concern about antibiotic resistant bacteria, there has been an increased interest in bacteriophages. Bacteriophages are high-specific viruses that only infect bacteria. The use of bacteriophages medicinally to treat bacteria is called phage therapy. Research in phage therapy gained momentum until the introduction of antibiotics. While the USA and other Western countries accepted antibiotics, the Soviet Union and their satellite nations still continued to research phages. Since the funding for research was supplied by the Soviet military, the results ...


Combining Orthogonal Trna/Synthatase Pair And Amber Codon Suppression To Genetically Encode Oxidative Damage In High Density Lipoproteins, Jaclyn Alatrash, Nicholas Gilliam, Alisha House, Valentin Gogonea Sep 2013

Combining Orthogonal Trna/Synthatase Pair And Amber Codon Suppression To Genetically Encode Oxidative Damage In High Density Lipoproteins, Jaclyn Alatrash, Nicholas Gilliam, Alisha House, Valentin Gogonea

Undergraduate Research Posters 2013

Apolipoprotein A-I (apoA-I) is the main protein constituent of high density lipoprotein (HDL - the “good cholesterol”). Oxidatively damaged apoA-I has been isolated from circulating plasma and atherosclerosis plaque with the amino acid residue tryptophan 72 (W72) of apoA-I identified as a primary oxidation site. ApoA-I designed to include specific oxidized amino acids can be used to further investigate the role of site-specific oxidative damage in atherosclerosis. Genetic encoding of oxidized amino acids through orthogonal tRNA/aminoacyl-tRNA synthetase (aaRS) pairs offers a reliable method for producing site-specific oxidized proteins. Our project involves the generation of Saccharomyces tryptophan-RS mutants for recognition of ...


Computational And Biochemical Approaches To Molecular Epidemiology, Michael Calhoun, Hannah Dysinger, David Hobbs, Ph.D., Katie Hailer, Ph.D. Aug 2013

Computational And Biochemical Approaches To Molecular Epidemiology, Michael Calhoun, Hannah Dysinger, David Hobbs, Ph.D., Katie Hailer, Ph.D.

2013 Undergraduate Research

Mining activity in Butte, Montana has taken place, or continues to take place, within the urban residence of Butte itself. This has led to urban areas with high concentrations of toxic metals such as arsenic, lead, copper, zinc, mercury and cadmium. Advances in protein study and gene sequencing has opened the possibility of finding molecular biomarkers whose presence, absence or morphological changes could indicate disease processes in populations exposed to environmental toxins. While in principle, biomarkers can be any chemicals or metabolites, as well as proteins and genes that are indicative of exposure to xenobiotics, this study seeks to identify ...


Helix Turn Helix Domain, David J. Hall Jan 2013

Helix Turn Helix Domain, David J. Hall

Protein Domains

Helix turn helix domain #3V1A. The helix-turn helix is a DNA-binding domain. The two alpha helices are the reading or recognition helices, which bind in a groove in the DNA and recognize specific gene regulatory sequences in the DNA.


Ig Domain, David J. Hall Jan 2013

Ig Domain, David J. Hall

Protein Domains

Ig domain #2CKN. This particular domain is named for the first protein in which it was found, the immunoglobulin. An immunoglobulin is a antibody. Antibodies are generated by our immune system to recognize the specific size, shape and charge of pathogens. This domain is also found on the extracellular portion of many receptors including the interleukin-1 family of receptors.


Sh3 Domain, David J. Hall Jan 2013

Sh3 Domain, David J. Hall

Protein Domains

SH3 domain #1NEB. Src-homology 3 (SH3) domains bind to Pro-rich peptides that form a left-handed poly-Pro type II helix, with the minimal consensus Pro-X-X-Pro. Each Pro is usually preceeded by an aliphatic residue. Each in the aliphatic-Pro pair binds to a hydrophobic pocket on the SH3 domain.